ArticleProceedings of the National Academy of Sciences of the United States of America1995
Expression of pax-6 during urodele eye development and lens regeneration.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 112 citations in OpenAlex.
- Parallel sensory compensation following independent subterranean colonization by groundwater salamanders (Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Comparative development and ocular histology between epigean and subterranean salamanders (PeerJ · 2021Article
- Comparative transcriptomics of limb regeneration: Identification of conserved expression changes among three species of Ambystoma.Genomics · 2019Article
- Granulin 1 Promotes Retinal Regeneration in Zebrafish.Investigative ophthalmology & visual science · 2018Article
- Lens regeneration: a historical perspective.The International journal of developmental biology · 2018Review
- Molecular and cellular aspects of amphibian lens regeneration.Progress in retinal and eye research · 2010Article
- Persistent expression of Pax3 in the neural crest causes cleft palate and defective osteogenesis in mice.The Journal of clinical investigation · 2008Article
- The lens-regenerating competence in the outer cornea and epidermis of larval Xenopus laevis is related to pax6 expression.Journal of anatomy · 2008Article
- Signaling during lens regeneration.Seminars in cell & developmental biology · 2006Review
- The role of Pax-6 in lens regeneration.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- How to build and rebuild a lens.Journal of anatomy · 2006Review
- Eye on regeneration.Anatomical record. Part B, New anatomist · 2005Review
- Transdifferentiation, metaplasia and tissue regeneration.Organogenesis · 2004Article
- A critical role for thrombin in vertebrate lens regeneration.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2004Review
- Reverse homeosis in homeotically reconstructed ribbonworms.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Isolation and expression of a Pax-6 gene in the regenerating and intact Planarian Dugesia(G)tigrina.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Conservation of fibroblast growth factor function in lens regeneration.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Regeneration as an evolutionary variable.Journal of anatomyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regeneration of eye tissues, such as lens, seen in some urodeles involves dedifferentiation of the dorsal pigmented epithelium and subsequent differentiation to lens cells. Such spatial regulation implies possible action of genes known to be specific for particular cell lineages and/or axis. Hox genes have been the best examples of genes for such actions. We have, therefore, investigated the possibility that such genes are expressed during lens regeneration in the newt. The pax-6 gene (a gene that contains a homeobox and a paired box) has been implicated in the development of the eye and lens determination in various species ranging from Drosophila to human and, because of these properties, could be instrumental in the regeneration of the urodele eye tissues as well. We present data showing that pax-6 transcripts are present in the developing and the regenerating eye tissues. Furthermore, expression in eye tissues, such as in retina, declines when a urodele not capable of lens regeneration (axolotl) surpasses the embryonic stages. Such a decline is not seen in adult newts capable of lens regeneration. This might indicate a vital role of pax-6 in newt lens regeneration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.