ArticleProceedings of the National Academy of Sciences of the United States of America1995
Molecular cloning and characterization of a conserved nuclear serine(threonine) protein kinase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 78 citations in OpenAlex.
- NDR1/2 kinases regulate cell polarization and cell motility through Cdc42 GTPase and Pard3 signaling in mammalian cells.bioRxiv : the preprint server for biology · 2025Article
- The Role of Mammalian STK38 in DNA Damage Response and Targeting for Radio-Sensitization.Cancers · 2023Review
- Uncovering new insights into the role of the ubiquitin ligase Smurf1 on the regulation of innate immune signaling and resistance to infection.Frontiers in immunology · 2023Review
- Some Insights into the Regulation of Cardiac Physiology and Pathology by the Hippo Pathway.Biomedicines · 2022Review
- The Emerging Roles of NDR1/2 in Infection and Inflammation.Frontiers in immunology · 2020Review
- Mob Family Proteins: Regulatory Partners in Hippo and Hippo-Like Intracellular Signaling Pathways.Frontiers in cell and developmental biology · 2020Review
- Two Antagonistic Hippo Signaling Circuits Set the Division Plane at the Medial Position in the CiliateGenetics · 2019Article
- NDR2 promotes the antiviral immune response via facilitating TRIM25-mediated RIG-I activation in macrophages.Science advances · 2019Article
- Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop.Nature communications · 2018Article
- Review
- STK38 is a critical upstream regulator of MYC's oncogenic activity in human B-cell lymphoma.Oncogene · 2013Article
- Conserved Orb6 phosphorylation sites are essential for polarized cell growth in Schizosaccharomyces pombe.PloS one · 2012Article
- The Irish potato famine pathogen Phytophthora infestans translocates the CRN8 kinase into host plant cells.PLoS pathogens · 2012Article
- The T-loop extension of the tomato protein kinase AvrPto-dependent Pto-interacting protein 3 (Adi3) directs nuclear localization for suppression of plant cell death.The Journal of biological chemistry · 2010Article
- Mutations in the C-terminus of the conserved NDR kinase, Cbk1p of Saccharomyces cerevisiae, make the protein independent of upstream activators.Molecular genetics and genomics : MGG · 2010Article
- Phosphoregulation of Cbk1 is critical for RAM network control of transcription and morphogenesis.The Journal of cell biology · 2006Article
- Depletion of Aspergillus nidulans cotA causes a severe polarity defect which is not suppressed by the nuclear migration mutation nudA2.Molecular genetics and genomics : MGG · 2006Article
- Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3.Molecular and cellular biology · 2005Article
- Human NDR kinases are rapidly activated by MOB proteins through recruitment to the plasma membrane and phosphorylation.Molecular and cellular biology · 2005Article
- Drosophila Mob family proteins interact with the related tricornered (Trc) and warts (Wts) kinases.Molecular biology of the cell · 2005Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human, Drosophila melanogaster, and Caenorhabditis elegans cDNA clones encoding homologues of a serine(threonine) protein kinase (EC 2.7.1.37) (designated Ndr protein kinase) have been isolated and sequenced. The human and Drosophila cDNAs predict polypeptides of 54 kDa and 52 kDa, respectively, which share approximately 80% amino acid similarity. Northern analysis of human tissues revealed a ubiquitously expressed 3.9-kb transcript. Recombinant GST-Ndr underwent intramolecular autophosphorylation on serine and threonine residues in vitro but failed to transphosphorylate several standard protein kinase substrates. Transfection of the human cDNA into COS-1 cells resulted in the appearance of an intense nuclear staining in cells analyzed by indirect immunofluorescence; deletion mutagenesis identified a short basic peptide, KRKAETWKRNRR, responsible for the nuclear accumulation of Ndr. Thus, Ndr is a conserved and widely expressed nuclear protein kinase. The closest known relative of this previously uncharacterized kinase is Dbf2, a budding yeast protein kinase required for the completion of nuclear division.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.