ArticleProceedings of the National Academy of Sciences of the United States of America1995
Replication protein A binds to regulatory elements in yeast DNA repair and DNA metabolism genes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 60 citations in OpenAlex.
- RPA1 binding to NRF2 switches ARE-dependent transcriptional activation to ARE-NRE-dependent repression.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Article
- Methanosarcina acetivorans flap endonuclease 1 activity is inhibited by a cognate single-stranded-DNA-binding protein.Journal of bacteriology · 2006Article
- Genomic analysis of stationary-phase and exit in Saccharomyces cerevisiae: gene expression and identification of novel essential genes.Molecular biology of the cell · 2004Article
- Article
- The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene.Molecular and cellular biology · 2003Article
- Autoimmunity to the M(r) 32,000 subunit of replication protein A in breast cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2002Article
- Replication protein A is sequentially phosphorylated during meiosis.Nucleic acids research · 2001Article
- The set1Delta mutation unveils a novel signaling pathway relayed by the Rad53-dependent hyperphosphorylation of replication protein A that leads to transcriptional activation of repair genes.Genes & development · 2001Article
- UV-induced hyperphosphorylation of replication protein a depends on DNA replication and expression of ATM protein.Molecular biology of the cell · 2001Article
- Regulatory networks revealed by transcriptional profiling of damaged Saccharomyces cerevisiae cells: Rpn4 links base excision repair with proteasomes.Molecular and cellular biology · 2000Article
- RBT1, a novel transcriptional co-activator, binds the second subunit of replication protein A.Nucleic acids research · 2000Article
- Global response of Saccharomyces cerevisiae to an alkylating agent.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- In vitro analysis of the zinc-finger motif in human replication protein A.The Biochemical journal · 1999Article
- Role of UME6 in transcriptional regulation of a DNA repair gene in Saccharomyces cerevisiae.Molecular and cellular biology · 1997Article
- Expression of an ortholog of replication protein A1 (RPA1) is induced by gibberellin in deepwater rice.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Analysis of a meiosis-specific URS1 site: sequence requirements and involvement of replication protein A.Molecular and cellular biology · 1997Article
- Denaturation of the simian virus 40 origin of replication mediated by human replication protein A.Molecular and cellular biology · 1997Article
- Complex formation between p53 and replication protein A inhibits the sequence-specific DNA binding of p53 and is regulated by single-stranded DNA.Molecular and cellular biology · 1997Article
- The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Saccharomyces cerevisiae responds to DNA damage by arresting cell cycle progression (thereby preventing the replication and segregation of damaged chromosomes) and by inducing the expression of numerous genes, some of which are involved in DNA repair, DNA replication, and DNA metabolism. Induction of the S. cerevisiae 3-methyladenine DNA glycosylase repair gene (MAG) by DNA-damaging agents requires one upstream activating sequence (UAS) and two upstream repressing sequences (URS1 and URS2) in the MAG promoter. Sequences similar to the MAG URS elements are present in at least 11 other S. cerevisiae DNA repair and metabolism genes. Replication protein A (Rpa) is known as a single-stranded-DNA-binding protein that is involved in the initiation and elongation steps of DNA replication, nucleotide excision repair, and homologous recombination. We now show that the MAG URS1 and URS2 elements form similar double-stranded, sequence-specific, DNA-protein complexes and that both complexes contain Rpa. Moreover, Rpa appears to bind the MAG URS1-like elements found upstream of 11 other DNA repair and DNA metabolism genes. These results lead us to hypothesize that Rpa may be involved in the regulation of a number of DNA repair and DNA metabolism genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.