ArticleProceedings of the National Academy of Sciences of the United States of America1995
Agouti regulation of intracellular calcium: role in the insulin resistance of viable yellow mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 143 citations in OpenAlex.
- The effect of increasing dairy calcium intake of adolescent girls on changes in body fat and weight.The American journal of clinical nutrition · 2017Trial
- Exploring the Potential of Carotenoids in Obesity Management: A Comprehensive Overview.Recent advances in food, nutrition & agriculture · 2025Review
- Verapamil-loaded supramolecular hydrogel patch attenuates metabolic dysfunction-associated fatty liver disease via restoration of autophagic clearance of aggregated proteins and inhibition of NLRP3.Biomaterials research · 2023Article
- Exposure to permethrin promotes high fat diet-induced weight gain and insulin resistance in male C57BL/6J mice.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2018Article
- Increased mitochondrial calcium uniporter in adipocytes underlies mitochondrial alterations associated with insulin resistance.American journal of physiology. Endocrinology and metabolism · 2017Article
- Ion Channels in Obesity: Pathophysiology and Potential Therapeutic Targets.Frontiers in pharmacology · 2016Review
- Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes.Cell metabolism · 2015Review
- Bone Remodeling and Energy Metabolism: New Perspectives.Bone research · 2013Review
- VDR haploinsufficiency impacts body composition and skeletal acquisition in a gender-specific manner.Calcified tissue international · 2011Article
- Function of the hypothalamo-hypophyseal-adrenal system in mice with ectopic hyperproduction of the agouti protein.Neuroscience and behavioral physiology · 2005Article
- Review
- An agouti mutation lacking the basic domain induces yellow pigmentation but not obesity in transgenic mice.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Nutritional and endocrine modulation of intracellular calcium: implications in obesity, insulin resistance and hypertension.Molecular and cellular biochemistry · 1998Review
- Characterization of genes modulated during pheomelanogenesis using differential display.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Interaction of Agouti protein with the melanocortin 1 receptor in vitro and in vivo.Genes & development · 1998Article
- Linkage and association studies between the melanocortin receptors 4 and 5 genes and obesity-related phenotypes in the Québec Family Study.Molecular medicine (Cambridge, Mass.) · 1997Article
- Article
- Modulation of murine melanocyte function in vitro by agouti signal protein.The EMBO journal · 1997Article
- Combined effects of insulin treatment and adipose tissue-specific agouti expression on the development of obesity.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several dominant mutations at the agouti locus in the mouse cause a syndrome of marked obesity, hyperinsulinemia, and insulin resistance. Although it is known that the agouti gene is expressed in an ectopic manner in these mutants, the precise mechanism by which the agouti gene product mediates these effects is unclear. Since intracellular Ca2+ is believed to play a role in mediating insulin action and dysregulation of Ca2+ flux is observed in diabetic animals and humans, we examined the status of intracellular Ca2+ in mice carrying the dominant agouti allele, viable yellow (Avy). We show here that in mice carrying this mutation, the intracellular free calcium concentration ([Ca2+]i) is elevated in skeletal muscle, and the degree of elevation is closely correlated with the degree to which the mutant traits are expressed in individual animals. Moreover, we demonstrate that the agouti gene product is capable of inducing increased [Ca2+]i in cultured and freshly isolated skeletal muscle myocytes from wild-type mice. Based on these findings, we present a model in which we propose that the agouti polypeptide promotes insulin resistance in mutant animals through its ability to increase [Ca2+]i.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.