ArticlePflugers Archiv : European journal of physiology1995
Immunolocalisation of nucleoside transporters in human placental trophoblast and endothelial cells: evidence for multiple transporter isoforms.
Article in Pflugers Archiv : European journal of physiology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 46 citations in OpenAlex.
- Addressing the Clinical Importance of Equilibrative Nucleoside Transporters in Drug Discovery and Development.Clinical pharmacology and therapeutics · 2023Review
- Drug Transporters at the Human Blood-Testis Barrier.Drug metabolism and disposition: the biological fate of chemicals · 2023Review
- Chemotherapy in pregnancy: exploratory study of the effects of paclitaxel on the expression of placental drug transporters.Investigational new drugs · 2019Article
- Regulation of human placental drug transporters in HCV infection and their influence on direct acting antiviral medications.Placenta · 2018Article
- The role of the equilibrative nucleoside transporter 1 on tissue and fetal distribution of ribavirin in the mouse.Biopharmaceutics & drug disposition · 2016Article
- Excretion of biliary compounds during intrauterine life.World journal of gastroenterology · 2009Review
- Glutamate mediates acute glucose transport inhibition in hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Glutamate triggers rapid glucose transport stimulation in astrocytes as evidenced by real-time confocal microscopy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Functional and molecular characteristics of Na(+)-dependent nucleoside transporters.Pharmaceutical research · 1997Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
Polyclonal antibodies raised against the human erythrocyte nucleoside transporter were used to investigate the distribution of the nucleoside transporters in the placenta. Immunoblots of brush-border membranes isolated from the human syncytiotrophoblast revealed a cross-reactive species that co-migrated with the erythrocyte nucleoside transporter as a broad band of apparent M(r) 55,000. In contrast, no labelling was detected in basal membranes containing a similar number of equilibrative nucleoside transporters as assessed by nitrobenzylthioinosine (NBMPR)-binding. The absence of cross-reactive epitopes in basal membranes and their presence in brush-border membranes was confirmed by confocal immunofluorescence microscopy. These results suggest that at least two isoforms of the NBMPR-sensitive nucleoside transporter are present in the human placenta. The lumenal surfaces of fetal capillaries, small placental vessels and umbilical vein were also strongly labelled by the antibody, a finding that suggests that the high fetal-placental adenosine uptake previously reported is due to endothelial transporters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.