ArticleMolecular and cellular biology1995
Serum induction of MEF2/RSRF expression in vascular myocytes is mediated at the level of translation.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 55 citations in OpenAlex.
- Generation of a mef2aa:EGFP transgenic zebrafish line that expresses EGFP in muscle cells.Fish physiology and biochemistry · 2017Article
- The control operated by the cell cycle machinery on MEF2 stability contributes to the downregulation of CDKN1A and entry into S phase.Molecular and cellular biology · 2015Article
- Small leucine zipper protein (sLZIP) negatively regulates skeletal muscle differentiation via interaction with α-actinin-4.The Journal of biological chemistry · 2014Article
- Promoter variant-dependent mRNA expression of the MEF2A in longissimus dorsi muscle in cattle.DNA and cell biology · 2012Article
- MEF2 is regulated by CaMKIIδ2 and a HDAC4-HDAC5 heterodimer in vascular smooth muscle cells.The Biochemical journal · 2012Article
- Calmodulin kinase II is required for angiotensin II-mediated vascular smooth muscle hypertrophy.American journal of physiology. Heart and circulatory physiology · 2010Article
- Rapid recruitment of temporally distinct vascular gene sets by estrogen.Molecular endocrinology (Baltimore, Md.) · 2008Article
- Nemo-like kinase-myocyte enhancer factor 2A signaling regulates anterior formation in Xenopus development.Molecular and cellular biology · 2007Article
- Regulation of smooth muscle cell migration and integrin expression by the Gax transcription factor.The Journal of clinical investigation · 1999Article
- Dominant negative murine serum response factor: alternative splicing within the activation domain inhibits transactivation of serum response factor binding targets.Molecular and cellular biology · 1999Article
- Adenovirus-mediated delivery of the Gax transcription factor to rat carotid arteries inhibits smooth muscle proliferation and induces apoptosis.Gene therapy · 1999Article
- The MEF2A 3' untranslated region functions as a cis-acting translational repressor.Molecular and cellular biology · 1997Article
- Myocyte-specific enhancer binding factor 2C expression in fetal mouse brain development.Journal of molecular neuroscience : MN · 1997Article
- Combinatorial control of muscle development by basic helix-loop-helix and MADS-box transcription factors.Proceedings of the National Academy of Sciences of the United States of America · 1996Review
- Regulation of Gax homeobox gene transcription by a combination of positive factors including myocyte-specific enhancer factor 2.Molecular and cellular biology · 1995Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Vascular smooth muscle cells (VSMCs) reversibly coordinate the expression of VSMC-specific genes and the genes required for cell cycle progression. Here we demonstrate that isoforms of the MEF2/RSRF transcription factor are expressed in VSMCs and in vascular tissue. The MEF2A DNA-binding activity was upregulated when quiescent VSMCs were stimulated to proliferate with serum mitogens. The serum-induction of MEF2A DNA-binding activity occurred approximately 4 h following serum activation, and this correlated with an increase in the level of MEF2A protein without changes in the level of MEF2A mRNA or protein stability. These results indicate that MEF2A induction by serum is regulated at the level of translation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.