ArticleMolecular and cellular biology1995
Suppression of mammary epithelial cell differentiation by the helix-loop-helix protein Id-1.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
70 citing papers in PubMed, 188 citations in OpenAlex.
- Smoking-induced suppression of β-casein in milk is associated with an increase in miR-210-5p expression in mammary epithelia.Biochemistry and biophysics reports · 2024Article
- Inhibitor of DNA binding proteins revealed as orchestrators of steady state, stress and malignant hematopoiesis.Frontiers in immunology · 2022Review
- Mice Deficient in the RNA-Binding Protein Zfp871 Are Prone to Early Death and Steatohepatitis in Part through the p53-Mdm2 Axis.Molecular cancer research : MCR · 2021Article
- The Id-protein family in developmental and cancer-associated pathways.Cell communication and signaling : CCS · 2017Review
- Sustained delivery of siRNA/PEI complex from in situ forming hydrogels potently inhibits the proliferation of gastric cancer.Journal of experimental & clinical cancer research : CR · 2016Article
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- A pooled shRNA screen for regulators of primary mammary stem and progenitor cells identifies roles for Asap1 and Prox1.BMC cancer · 2015Article
- SPCA2 regulates Orai1 trafficking and store independent Ca2+ entry in a model of lactation.PloS one · 2013Article
- Downregulation of Id1 by small interfering RNA in gastric cancer inhibits cell growth via the Akt pathway.Molecular medicine reports · 2012Article
- Inhibitor of DNA-binding-1/inhibitor of differentiation-1 (ID-1) is implicated in various aspects of gastric cancer cell biology.Molecular biology reports · 2012Article
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- Microarray analysis of gene expression in West Nile virus-infected human retinal pigment epithelium.Molecular vision · 2012Article
- ID4 regulates mammary gland development by suppressing p38MAPK activity.Development (Cambridge, England) · 2011Article
- Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype.The Journal of biological chemistry · 2011Article
- A genetic strategy for combined screening and localized imaging of breast cancer.Molecular imaging and biology · 2011Article
- Redefining the expression and function of the inhibitor of differentiation 1 in mammary gland development.PloS one · 2010Article
- Mammary ductal growth is impaired in mice lacking leptin-dependent signal transducer and activator of transcription 3 signaling.Endocrinology · 2010Article
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- Estrogen-dependent and estrogen-independent mechanisms contribute to AIB1-mediated tumor formation.Cancer research · 2010Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Cell proliferation and differentiation are precisely coordinated during the development and maturation of the mammary gland, and this balance invariably is disrupted during carcinogenesis. Little is known about the cell-specific transcription factors that regulate these processes in the mammary gland. The mouse mammary epithelial cell line SCp2 grows well under standard culture conditions but arrests growth, forms alveolus-like structures, and expresses beta-casein, a differentiation marker, 4 to 5 days after exposure to basement membrane and lactogenic hormones (differentiation signals). We show that this differentiation entails a marked decline in the expression of Id-1, a helix-loop-helix (HLH) protein that inactivates basic HLH transcription factors in other cell types. SCp2 cells stably transfected with an Id-1 expression vector grew more rapidly than control cells under standard conditions, but in response to differentiation signals, they arrested growth and formed three-dimensional structures similar to those of control cells. Id-1-expressing cells did not, however, express beta-casein. Moreover, 8 to 10 days after receiving differentiation signals, they lost three-dimensional organization, invaded the basement membrane, and then resumed growth. SCp2 cells expressing an Id-1 antisense vector grew more slowly than controls; in response to differentiation signals, they remained stably growth arrested and fully differentiated, as did control cells. We suggest that Id-1 renders cells refractory to differentiation signals and receptive to growth signals by inactivating one or more basic HLH proteins that coordinate growth and differentiation in the mammary epithelium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.