ArticleMolecular and cellular biology1995
Quail Pax-6 (Pax-QNR) mRNAs are expressed from two promoters used differentially during retina development and neuronal differentiation.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 55 citations in OpenAlex.
- Autoregulation of Pax6 in neuronal cells is mediated by Pax6(5a), Pax6(ΔPD), SPARC, and p53.Molecular biology reports · 2022Article
- Review
- The Spectrum ofGenes · 2019Review
- Direct Conversion of Human Fibroblasts into Neural Progenitors Using Transcription Factors Enriched in Human ESC-Derived Neural Progenitors.Stem cell reports · 2017Article
- Hedgehog-dependent E3-ligase Midline1 regulates ubiquitin-mediated proteasomal degradation of Pax6 during visual system development.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- CTCF-Mediated and Pax6-Associated Gene Expression in Corneal Epithelial Cell-Specific Differentiation.PloS one · 2016Article
- Article
- AC and AG dinucleotide repeats in the PAX6 P1 promoter are associated with high myopia.Molecular vision · 2009Article
- Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization.Development (Cambridge, England) · 2007Article
- The MH1 domain of Smad3 interacts with Pax6 and represses autoregulation of the Pax6 P1 promoter.Nucleic acids research · 2007Article
- Pax6 regulation in retinal cells by CCCTC binding factor.Investigative ophthalmology & visual science · 2006Article
- Long-range downstream enhancers are essential for Pax6 expression.Developmental biology · 2006Article
- Positive autoregulation of the transcription factor Pax6 in response to increased levels of either of its major isoforms, Pax6 or Pax6(5a), in cultured cells.BMC developmental biology · 2006Article
- The PAX6 gene is activated by the basic helix-loop-helix transcription factor NeuroD/BETA2.The Biochemical journal · 2003Article
- Activation of the human PAX6 gene through the exon 1 enhancer by transcription factors SEF and Sp1.Nucleic acids research · 2001Article
- Involvement of poly (ADP-ribose)-polymerase in the Pax-6 gene regulation in neuroretina.Oncogene · 1999Article
- The mouse ADP-ribosylation factor-like 4 gene: two separate promoters direct specific transcription in tissues and testicular germ cell.The Biochemical journal · 1998Article
- Overexpression of A-myb induces basic fibroblast growth factor-dependent proliferation of chicken neuroretina cells.Journal of virology · 1997Article
- Characterization of a new melanocyte-specific gene (QNR-71) expressed in v-myc-transformed quail neuroretina.The EMBO journal · 1996Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During investigations on the regulation of the Pax-6 gene, we characterized a cDNA from quail neuroretina showing a 5' untranslated region distinct from that previously described and initiated from an internal promoter. Using RNase protection and primer extension mapping, we localized this second quail Pax-6 promoter, termed P1. As reported for the already described P0 promoter, P1 was also transactivated in vitro by the p46Pax-QNR protein. RNase protection assays performed with quail neuroretina RNA showed that P1-initiated mRNAs were detected before the P0-initiated mRNAs, remained constant up to embryonic day 8, and decreased slowly thereafter whereas, P0-initiated mRNAs accumulated up to embryonic day 8. In contrast, quail retinal pigmented epithelium expressed only the P1-initiated mRNAs. Transformation of these cells by the v-myc oncogene induced neuronal traits in the culture, which thereafter, in addition to the P1-initiated mRNAs, expressed Pax-QNR from the P0 promoter. These results suggest that expression of the quail Pax-6 gene is under the control of different regulators through alternate promoters, P0 being activated at the onset of neuronal differentiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.