ArticleMolecular and cellular biology1995
Nutrient availability and the RAS/cyclic AMP pathway both induce expression of ribosomal protein genes in Saccharomyces cerevisiae but by different mechanisms.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44 citing papers in PubMed, 103 citations in OpenAlex.
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- PKA and HOG signaling contribute separable roles to anaerobic xylose fermentation in yeast engineered for biofuel production.PloS one · 2019Article
- Control of nongenetic heterogeneity in growth rate and stress tolerance of Saccharomyces cerevisiae by cyclic AMP-regulated transcription factors.PLoS genetics · 2018Article
- Opposing PKA and Hog1 signals control the post-transcriptional response to glucose availability in Cryptococcus neoformans.Molecular microbiology · 2016Article
- Exploiting the yeast stress-activated signaling network to inform on stress biology and disease signaling.Current genetics · 2015Review
- Transcriptome analysis of cyclic AMP-dependent protein kinase A-regulated genes reveals the production of the novel natural compound fumipyrrole by Aspergillus fumigatus.Molecular microbiology · 2015Article
- Discovery of Chromatin-Associated Proteins via Sequence-Specific Capture and Mass Spectrometric Protein Identification in Saccharomyces cerevisiae.Journal of proteome research · 2014Article
- Repression of class I transcription by cadmium is mediated by the protein phosphatase 2A.Nucleic acids research · 2013Article
- Functional analyses of NSF1 in wine yeast using interconnected correlation clustering and molecular analyses.PloS one · 2013Article
- Gcn4p-mediated transcriptional repression of ribosomal protein genes under amino-acid starvation.The EMBO journal · 2011Article
- Glucose signaling-mediated coordination of cell growth and cell cycle in Saccharomyces cerevisiae.Sensors (Basel, Switzerland) · 2010Review
- Global transcriptome and deletome profiles of yeast exposed to transition metals.PLoS genetics · 2008Article
- Serial analysis of gene expression reveals conserved links between protein kinase A, ribosome biogenesis, and phosphate metabolism in Ustilago maydis.Eukaryotic cell · 2005Article
- Central role of Ifh1p-Fhl1p interaction in the synthesis of yeast ribosomal proteins.The EMBO journal · 2005Article
- Tor and cyclic AMP-protein kinase A: two parallel pathways regulating expression of genes required for cell growth.Eukaryotic cell · 2005Article
- Cold adaptation in budding yeast.Molecular biology of the cell · 2004Article
- A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size.Genes & development · 2004Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
By differential hybridization, we identified a number of genes in Saccharomyces cerevisiae that are activated by addition of cyclic AMP (cAMP) to cAMP-depleted cells. A majority, but not all, of these genes encode ribosomal proteins. While expression of these genes is also induced by addition of the appropriate nutrient to cells starved for a nitrogen source or for a sulfur source, the pathway for nutrient activation of ribosomal protein gene transcription is distinct from that of cAMP activation: (i) cAMP-mediated transcriptional activation was blocked by prior addition of an inhibitor of protein synthesis whereas nutrient-mediated activation was not, and (ii) cAMP-mediated induction of expression occurred through transcriptional activation whereas nutrient-mediated induction was predominantly a posttranscriptional response. Transcriptional activation of the ribosomal protein gene RPL16A by cAMP is mediated through a upstream activation sequence element consisting of a pair of RAP1 binding sites and sequences between them, suggesting that RAP1 participates in the cAMP activation process. Since RAP1 protein decays during starvation for cAMP, regulation of ribosomal protein genes under these conditions may directly relate to RAP1 protein availability. These results define additional critical targets of the cAMP-dependent protein kinase, suggest a mechanism to couple ribosome production to the metabolic activity of the cell, and emphasize that nutrient regulation is independent of the RAS/cAMP pathway.
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