ArticleMolecular and cellular biology1995
A Myc-associated zinc finger protein binding site is one of four important functional regions in the CD4 promoter.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 70 citations in OpenAlex.
- PUF60-Regulated Isoform Switching of MAZ Modulates Gastric Cancer Cell Migration.Cancer medicine · 2025Article
- Tissue and cell-type-specific transduction using rAAV vectors in lung diseases.Journal of molecular medicine (Berlin, Germany) · 2021Review
- MAZ induces MYB expression during the exit from quiescence via the E2F site in the MYB promoter.Nucleic acids research · 2017Article
- Injury-elicited stressors alter endogenous retrovirus expression in lymphocytes depending on cell type and source lymphoid organ.BMC immunology · 2013Article
- Quantitative proteomic identification of MAZ as a transcriptional regulator of muscle-specific genes in skeletal and cardiac myocytes.Molecular and cellular biology · 2008Article
- Nucleoprotein structure of the CD4 locus: implications for the mechanisms underlying CD4 regulation during T cell development.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Transcriptional regulation of human eosinophil RNases by an evolutionary- conserved sequence motif in primate genome.BMC molecular biology · 2007Article
- Cytokine-responsive induction of SAF-1 activity is mediated by a mitogen-activated protein kinase signaling pathway.Molecular and cellular biology · 2002Article
- Negative regulation of CD4 gene expression by a HES-1-c-Myb complex.Molecular and cellular biology · 2001Article
- Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Krüppel-like factor, a novel zinc finger repressor.Molecular and cellular biology · 2000Article
- Precise arrangement of factor-binding sites is required for murine CD4 promoter function.Nucleic acids research · 2000Article
- Fetal Alz-50 clone 1 (FAC1) protein interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity.Biochemistry · 2000Article
- Subclass-specific nuclear localization of a novel CD4 silencer binding factor.The Journal of experimental medicine · 1999Article
- The notch pathway intermediate HES-1 silences CD4 gene expression.Molecular and cellular biology · 1998Article
- Isolation and functional characterization of cDNA of serum amyloid A-activating factor that binds to the serum amyloid A promoter.Molecular and cellular biology · 1998Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The CD4 promoter plays an important role in the developmental control of CD4 transcription. In this report, we show that the minimal CD4 promoter has four factor binding sites, each of which is required for full function. Using biochemical and mutagenesis analyses, we determined that multiple nuclear factors bind to these independent sites. We determined that an initiator-like sequence present at the cap site and an Ets consensus sequence are required for full promoter function. We also demonstrate that the Myc-associated zinc finger protein (MAZ) appears to be the predominant factor binding to one of these sites. This last site closely resembles the ME1a1 G3AG4AG3 motif previously shown to be a critical element in the P2 promoter of the c-myc gene. We therefore believe that the MAZ transcription factor is also likely to play an important role in the control of developmental expression of the CD4 gene.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.