ArticleMolecular and cellular biology1995
The myc intron-binding polypeptide associates with RFX1 in vivo and binds to the major histocompatibility complex class II promoter region, to the hepatitis B virus enhancer, and to regulatory regions of several distinct viral genes.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- RFX1 and RFX3 Transcription Factors Interact with the D Sequence of Adeno-Associated Virus Inverted Terminal Repeat and Regulate AAV Transduction.Scientific reports · 2018Article
- Identification and characterization of human MIBP1 gene in glioma cell differentiation.Journal of molecular neuroscience : MN · 2014Article
- Immune-related functions of the Hivep gene family in East African cichlid fishes.G3 (Bethesda, Md.) · 2013Article
- Spermatogenesis associated 4 promotes Sertoli cell proliferation modulated negatively by regulatory factor X1.PloS one · 2013Article
- Study of FoxA pioneer factor at silent genes reveals Rfx-repressed enhancer at Cdx2 and a potential indicator of esophageal adenocarcinoma development.PLoS genetics · 2011Article
- The G1613A mutation in the HBV genome affects HBeAg expression and viral replication through altered core promoter activity.PloS one · 2011Article
- Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts.The Journal of biological chemistry · 2009Article
- Interaction between STAT-3 and HNF-3 leads to the activation of liver-specific hepatitis B virus enhancer 1 function.Journal of virology · 2002Article
- The Epstein-Barr virus promoter initiating B-cell transformation is activated by RFX proteins and the B-cell-specific activator protein BSAP/Pax5.Journal of virology · 2000Article
- Disruption of Myc-tubulin interaction by hyperphosphorylation of c-Myc during mitosis or by constitutive hyperphosphorylation of mutant c-Myc in Burkitt's lymphoma.Molecular and cellular biology · 2000Article
- Induction of Myc-intron-binding polypeptides MIBP1 and RFX1 during retinoic acid-mediated differentiation of haemopoietic cells.The Biochemical journal · 2000Article
- Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains.Molecular and cellular biology · 1999Article
- The transcriptional activation and repression domains of RFX1, a context-dependent regulator, can mutually neutralize their activities.Nucleic acids research · 1997Article
- Interactions of the transcription factors MIBP1 and RFX1 with the EP element of the hepatitis B virus enhancer.Journal of virology · 1996Article
- A consensus motif in the RFX DNA binding domain and binding domain mutants with altered specificity.Molecular and cellular biology · 1996Article
- RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom.Nucleic acids research · 1996Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We demonstrated that MIF-1, identified initially as a binding activity that associated with the intron I element of the c-myc gene, consists of two polypeptides, the myc intron-binding peptide (MIBP1) and the major histocompatibility class II promoter-binding protein, RFX1. Using a polyclonal antiserum directed against either oligonucleotide affinity-purified MIBP1 or a peptide derived from RFX1, we showed that MIBP1 and RFX1 are distinct molecules that associate in vivo and are both present in DNA-protein complexes at the c-myc (MIF-1) and major histocompatibility complex class II (RFX1) binding sites. We have also found that MIBP1 and RFX1 bind to a regulatory site (termed EP) required for enhancer activity of hepatitis B virus. In addition, we have identified MIF-1-like sequences within regulatory regions of several other viral genes and have shown that MIBP1 binds to these sites in cytomegalovirus, Epstein-Barr virus, and polyomavirus. We have also demonstrated that the MIF-1 and EP elements can function as silencers in the hepatocarcinoma HepG2 and the cervical carcinoma HeLa cell lines. These findings indicate that MIBP1 and EP/RFX1 can associate in vivo and may regulate the expression of several distinct cellular and viral genes.
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