ReviewLipids1995
Very long chain fatty acids in higher animals--a review.
Review in Lipids, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 194 citations in OpenAlex.
- Glia dysfunction in schizophrenia: evidence of possible therapeutic effects of nervonic acid in a preclinical model.Psychopharmacology · 2024Article
- Article
- Behavioral and genetic architecture of fear conditioning and related phenotypes.Neurobiology of learning and memory · 2023Article
- Sperm very long-chain polyunsaturated fatty acids: relation to semen parameters and live birth outcome in a multicenter trial.Fertility and sterility · 2023Article
- The transmission of pottery technology among prehistoric European hunter-gatherers.Nature human behaviour · 2023Article
- Fatty Acids of Echinoderms: Diversity, Current Applications and Future Opportunities.Marine drugs · 2022Review
- Influence of very-long-chain polyunsaturated fatty acids on membrane structure and dynamics.Biophysical journal · 2022Article
- Genomic and transcriptomic analyses provide insights into valuable fatty acid biosynthesis and environmental adaptation of yellowhorn.Frontiers in plant science · 2022Article
- Proteomics analysis reveals the effect of 1α,25(OH)Scientific reports · 2021Article
- Alterations in Glycerolipid and Fatty Acid Metabolic Pathways in Alzheimer's Disease Identified by Urinary Metabolic Profiling: A Pilot Study.Frontiers in neurology · 2021Article
- A Review of Nervonic Acid Production in Plants: Prospects for the Genetic Engineering of High Nervonic Acid Cultivars Plants.Frontiers in plant science · 2021Review
- The Acer truncatum genome provides insights into nervonic acid biosynthesis.The Plant journal : for cell and molecular biology · 2020Article
- Effects ofEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Naturally Occurring Nervonic Acid Ester Improves Myelin Synthesis by Human Oligodendrocytes.Cells · 2019Article
- PUCHI regulates very long chain fatty acid biosynthesis during lateral root and callus formation.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Transcriptome analysis reveals crucial genes involved in the biosynthesis of nervonic acid in woody Malania oleifera oilseeds.BMC plant biology · 2018Article
- Membrane glycomics reveal heterogeneity and quantitative distribution of cell surface sialylation.Chemical science · 2018Article
- Metabolomic Estimation of the Diagnosis and Onset Time of Permanent and Transient Cerebral Ischemia.Molecular neurobiology · 2018Article
- Alleviation of reactive oxygen species enhances PUFA accumulation inMetabolic engineering communications · 2018Article
- Elongation of very Long-Chain (>CLipids · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fatty acids with greater than 22 carbon atoms (very long chain fatty acids, VLCFA) are present in small amounts in most animal tissues. Saturated and monoenoic VLCFA are major components of brain, while the polyenoic VLCFA occur in significant amounts in certain specialized animal tissues such as retina and spermatozoa. Biosynthesis of VLCFA occurs by carbon chain elongation of shorter chain fatty acid precursors while beta-oxidation takes place almost exclusively in peroxisomes. Mitochondria are unable to oxidize VLCFA because they lack a specific VLCFA coenzyme A synthetase, the first enzyme in the beta-oxidation pathway. VLCFA accumulate in the tissues of patients with inherited abnormalities in peroxisomal assembly, and also in individuals with defects in enzymes catalyzing individual reactions along the beta-oxidation pathway. It is believed that the accumulation of VLCFA in patient tissues contributes to the severe pathological changes which are a feature of these conditions. However, little is known of the role of VLCFA in normal cellular processes, and of the molecular basis for their contribution to the disease process. The present review provides an outline of the current knowledge of VLCFA including their biosynthesis, degradation, possible function and involvement in human disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.