ArticleThe Journal of experimental medicine1995
Proliferation is a prerequisite for bacterial superantigen-induced T cell apoptosis in vivo.
Article in The Journal of experimental medicine, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 121 citations in OpenAlex.
- Platelets as a potential new immune coordinator in T cell-mediated aplastic anemia.Frontiers in oncology · 2025Review
- Apoptosis-mediated inhibition of human T-cell acute lymphoblastic leukemia upon treatment withFrontiers in immunology · 2023Article
- Therapeutic effects of glatiramer acetate and grafted CD115⁺ monocytes in a mouse model of Alzheimer's disease.Brain : a journal of neurology · 2015Article
- Superantigens subvert the neutrophil response to promote abscess formation and enhance Staphylococcus aureus survival in vivo.Infection and immunity · 2014Article
- An orally active immune adjuvant prepared from cones of Pinus sylvestris, enhances the proliferative phase of a primary T cell response.BMC complementary and alternative medicine · 2014Article
- Microscopic detection of viable Staphylococcus epidermidis in peri-implant tissue in experimental biomaterial-associated infection, identified by bromodeoxyuridine incorporation.Infection and immunity · 2010Article
- CD95, BIM and T cell homeostasis.Nature reviews. Immunology · 2009Review
- Regulation of Apoptosis by Gram-Positive Bacteria: Mechanistic Diversity and Consequences for Immunity.Current immunology reviews · 2006Article
- Without peripheral interference, thymic deletion is mediated in a cohort of double-positive cells without classical activation.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Acute septic arthritis.Clinical microbiology reviews · 2002Review
- APRIL modulates B and T cell immunity.The Journal of clinical investigation · 2002Article
- T-cell activation, proliferation and apoptosis in primary Listeria monocytogenes infection.Immunology · 2002Article
- Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy.The Journal of clinical investigation · 2001Article
- Potential mechanisms of human natural killer cell expansion in vivo during low-dose IL-2 therapy.The Journal of clinical investigation · 2000Article
- Dichotomy between naïve and memory CD4(+) T cell responses to Fas engagement.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- A two-step, two-signal model for the primary activation of precursor helper T cells.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Bolus injection of aqueous antigen leads to a high density of T-cell-receptor ligand in the spleen, transient T-cell activation and anergy induction.Immunology · 1998Article
- High levels of a major histocompatibility complex II-self peptide complex on dendritic cells from the T cell areas of lymph nodes.The Journal of experimental medicine · 1997Article
- Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc.The EMBO journal · 1996Article
- Stimulated human lamina propria T cells manifest enhanced Fas-mediated apoptosis.The Journal of clinical investigation · 1996Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Staphylococcal enterotoxin B (SEB) is a bacterial superantigen that binds to major histocompatibility complex class II molecules and selectively interacts with T cells that bear certain T cell receptor (TCR) V beta domains. Administration of SEB in adult mice results in initial proliferation of V beta 8+ T cells followed by a state of unresponsiveness resulting from a combination of clonal deletion and clonal anergy in the SEB-reactive population. At this time, it is unclear what relationship exists between the T cells that have proliferated and those that have been deleted or have become anergic. Here we show that only a fraction of the potentially reactive V beta 8+ T cells proliferate in response to SEB in vivo, and that all the cells that have proliferated eventually undergo apoptosis. Virtually no apoptosis can be detected in the nonproliferating V beta 8+ T cells. These data demonstrate a causal relationship between proliferation and apoptosis in response to SEB in vivo, and they further indicate that T cells bearing the same TCR V beta segment can respond differently to the same superantigen. The implications of this differential responsiveness in terms of activation and tolerance are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.