ArticleDiabetologia1995
Insulin resistance and abnormal albumin excretion in non-diabetic first-degree relatives of patients with NIDDM.
Article in Diabetologia, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 89 citations in OpenAlex.
- Utilization of Mind-Body Intervention for Integrative Health Care of COVID-19 Patients and Survivors.International journal of environmental research and public health · 2022Review
- Lipid mediators of insulin signaling in diabetic kidney disease.American journal of physiology. Renal physiology · 2019Review
- Glucose Transporters in Diabetic Kidney Disease-Friends or Foes?Frontiers in endocrinology · 2018Review
- 12-Lipoxygenase Inhibition on Microalbuminuria in Type-1 and Type-2 Diabetes Is Associated with Changes of Glomerular Angiotensin II Type 1 Receptor Related to Insulin Resistance.International journal of molecular sciences · 2016Article
- Insulin signaling: implications for podocyte biology in diabetic kidney disease.Current opinion in nephrology and hypertension · 2015Article
- A Family History of Diabetes Modifies the Association between Elevated Urine Albumin Concentration and Hyperglycemia in Nondiabetic Mexican Adolescents.Journal of diabetes research · 2015Article
- Lipid biology of the podocyte--new perspectives offer new opportunities.Nature reviews. Nephrology · 2014Review
- Impact of smoking on microalbuminuria and urinary albumin creatinine ratio in non-diabetic normotensive smokers.Indian journal of nephrology · 2014Article
- Podocyte-specific GLUT4-deficient mice have fewer and larger podocytes and are protected from diabetic nephropathy.Diabetes · 2014Article
- Cystatin C, CRP, log TG/HDLc and metabolic syndrome are associated with microalbuminuria in hypertension.Arquivos brasileiros de cardiologia · 2014Article
- Is uric acid an indicator of metabolic syndrome in the first-degree relatives of patients with type 2 diabetes?Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2012Article
- Podocytopathy in diabetes: a metabolic and endocrine disorder.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2011Review
- Predictors of incident albuminuria in the Framingham Offspring cohort.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2010Article
- Role of altered insulin signaling pathways in the pathogenesis of podocyte malfunction and microalbuminuria.Current opinion in nephrology and hypertension · 2009Review
- Insulin resistance, microalbuminuria, and chronic kidney disease.Current hypertension reports · 2008Article
- The -374 T/A polymorphism in the gene encoding RAGE is associated with diabetic nephropathy and retinopathy in type 1 diabetic patients.Diabetologia · 2006Article
- A 100-kDa urinary protein is associated with insulin resistance in offspring of type 2 diabetic patients.Diabetologia · 2005Article
- Microalbuminuria, an integrated marker of cardiovascular risk in essential hypertension.Journal of human hypertension · 2002Review
- Urinary albumin excretion in lean, overweight and obese glucose tolerant individuals: its relationship with dyslipidaemia, hyperinsulinaemia and blood pressure.Journal of human hypertension · 2001Article
- Lack of association between the Gly40Ser polymorphism in the glucagon receptor gene and NIDDM in Finland.Diabetologia · 1995Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microalbuminuria has recently been associated with insulin resistance in both insulin-dependent and non-insulin-dependent (NIDDM) diabetes mellitus. To establish whether microalbuminuria in non-diabetic subjects as well is associated with insulin resistance and associated abnormalities in glucose and lipid metabolism, oral glucose tolerance tests were performed with measurement of urinary albumin excretion rate, lipids and lipoproteins in 582 male non-diabetic first-degree relatives of patients with NIDDM. In addition, insulin sensitivity was assessed in 20 of these subjects with the euglycaemic hyperinsulinaemic clamp technique. Abnormal albumin excretion rate (AER), defined as AER 15-200 micrograms/min, was associated with higher systolic blood pressure (p < 0.05), higher fasting glucose values (p < 0.05), lower HDL-cholesterol (p < 0.05) and lower apolipoprotein A-I (p < 0.05) concentrations than observed in subjects with normal AER. The rate of glucose metabolism was lower in subjects with abnormal compared to subjects with normal albumin excretion rate (38.0 +/- 2.8 vs 47.3 +/- 2.4 mumol.kg lean body mass-1.min-1; p = 0.028). This difference was almost completely accounted for by a reduction in non-oxidative glucose metabolism (17.7 +/- 1.9 vs 27.4 +/- 2.7 mumol.kg lean body mass-1.min-1; p = 0.010), which correlated inversely with the AER (r = -0.543; p = 0.013). These results suggest that in non-diabetic individuals genetically predisposed to NIDDM, abnormal AER is associated with insulin resistance and abnormalities in glucose and lipid metabolism.
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