ArticleVirchows Archiv : an international journal of pathology1995
Changes in E-cadherin immunoreactivity in the adenoma-carcinoma sequence of the large bowel.
Article in Virchows Archiv : an international journal of pathology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Effect of E-cadherin on Prognosis of Colorectal Cancer: A Meta-Analysis Update.Molecular diagnosis & therapy · 2022Pooled it
- Cadherins down-regulation: towards a better understanding of their relevance in colorectal cancer.Histology and histopathology · 2020Review
- E-cadherin and NEDD9 expression in primary colorectal cancer, metastatic lymph nodes and liver metastases.Oncology letters · 2019Article
- Loss of E-cadherin promotes migration and invasion of cholangiocarcinoma cells and serves as a potential marker of metastasis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Down-regulation of CDH1 is associated with expression of SNAI1 in colorectal adenomas.PloS one · 2012Article
- E-cadherin expression pattern in primary colorectal carcinomas and their metastases reflects disease outcome.World journal of gastroenterology · 2006Article
- E-cadherin expression is homogeneously reduced in adenoma from patients with familial adenomatous polyposis: an immunohistochemical study of E-cadherin, beta-catenin and cyclooxygenase-2 expression.International journal of colorectal disease · 2004Article
- Paracrine cyclooxygenase-2-mediated signalling by macrophages promotes tumorigenic progression of intestinal epithelial cells.Oncogene · 2002Article
- Article
- Cadherin-catenin expression in primary colorectal cancer: a survival analysis.British journal of cancer · 1999Article
- Intestinal trefoil factor controls the expression of the adenomatous polyposis coli-catenin and the E-cadherin-catenin complexes in human colon carcinoma cells.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Expression of epithelial cadherin and cavernous sinus invasion in human pituitary adenomas.Journal of neuro-oncology · 1997Article
- Expression of E-cadherin-associated molecules (alpha-, beta-, and gamma-catenins and p120) in colorectal polyps.The American journal of pathology · 1997Article
- Stromelysin-3 expression in early (pT1) carcinomas and pseudoinvasive lesions of the colorectum.Virchows Archiv : an international journal of pathology · 1997Article
- Tumour recurrence is associated with Jass grouping but not with differences in E-cadherin expression in moderately differentiated Dukes' B colorectal cancers.Journal of clinical pathology · 1997Article
- E-cadherin (E-cad) expression in duct carcinoma in situ (DCIS) of the breast.Virchows Archiv : an international journal of pathology · 1997Article
- Prognostic significance of E-cadherin expression in human colorectal cancer tissue.Surgery today · 1997Article
- Expression of the E-cadherin-catenin cell adhesion complex in primary squamous cell carcinomas of the head and neck and their nodal metastases.British journal of cancer · 1997Article
- Downregulation of E-cadherin in the reparative epithelium of the human gastrointestinal tract.The American journal of pathology · 1996Article
- Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have used an avidin-biotin immunoperoxidase technique to localise epithelial cadherin (E-cadherin), a calcium-dependent cell-cell adhesion molecule, in 107 paraffin-embedded sections from 93 patients consisting of 24 with colorectal adenoma, 55 with rectal carcinoma and 14 with liver metastases. The corresponding primary colorectal tumours were also studied in these cases. E-cadherin was expressed by normal colorectal epithelial cells with typical membranous staining at the intercellular junctions. Loss of normal membranous E-cadherin expression and presence of cytoplasmic staining were found frequently in adenomas larger than 1 cm (P < 0.01), with high grade dysplasia and villous histology (P < 0.01). In primary rectal cancers, loss of membranous expression correlated with high tumour grade. No correlation was seen with Dukes and Jass stage, local extramural spread and 5-year recurrence rate. Complete loss of membranous E-cadherin immunoreactivity was seen in 7/14 (50%) liver metastases in which 6/7 (86%) showed intense membranous E-cadherin immunoreactivity in the corresponding primary tumour. Our data indicate that changes in E-cadherin immunoreactivity and cellular localisation correlate with size, severe dysplasia in adenomas and tumour grade in carcinomas. However, there seems to be no correlation between loss of membranous E-cadherin immunoreactivity and the invasive and metastatic potential of the carcinomas.
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