ArticleActa neuropathologica1995
Differential expression of cell adhesion molecules (CAM), neural CAM and epithelial cadherin in ependymomas and choroid plexus tumors.
Article in Acta neuropathologica, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 75 citations in OpenAlex.
- Two illustrative cases of papillary tumor of the pineal region: Clinical presentation, management, and outcomes.Surgical neurology international · 2025Article
- E-Cadherin Is Expressed in Epithelial Cells of the Choroid Plexus in Human and Mouse Brains.Current issues in molecular biology · 2023Article
- Adenosine APurinergic signalling · 2023Article
- The blood cerebrospinal fluid barrier orchestrates immunosurveillance, immunoprotection, and immunopathology in the central nervous system.BMB reports · 2021Review
- Next generation DNA sequencing of atypical choroid plexus papilloma of brain: Identification of novel mutations in a female patient by Ion Proton.Oncology letters · 2019Article
- Choroid plexus carcinoma with neuronal and glial differentiation in a 7-week-old male Sprague-Dawley rat.The Journal of veterinary medical science · 2018Article
- Brain barriers: Crosstalk between complex tight junctions and adherens junctions.The Journal of cell biology · 2015Review
- Combined Analysis of SNP Array Data Identifies Novel CNV Candidates and Pathways in Ependymoma and Mesothelioma.BioMed research international · 2015Article
- Ventriculomegaly associated with ependymal gliosis and declines in barrier integrity in the aging human and mouse brain.Aging cell · 2014Article
- Fourth ventricular ependymoma with a distant intraventricular metastasis: Report of a rare case.Journal of neurosciences in rural practice · 2013Article
- Choroid plexus papillomas: advances in molecular biology and understanding of tumorigenesis.Neuro-oncology · 2013Review
- Choroid plexus tumors: A clinico-pathological and neuro-radiological study of 23 cases.Asian journal of neurosurgery · 2013Article
- Fgf2 is expressed in human and murine embryonic choroid plexus and affects choroid plexus epithelial cell behaviour.Cerebrospinal fluid research · 2008Article
- Subventricular zone-mediated ependyma repair in the adult mammalian brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Choroid plexus acinar adenoma: a case report.Journal of neuro-oncology · 2007Article
- Asymmetric localization of Notch2 on the microvillous surface in choroid plexus epithelial cells.Histochemistry and cell biology · 2007Article
- Expression of epithelial cadherin and cavernous sinus invasion in human pituitary adenomas.Journal of neuro-oncology · 1997Article
- The molecular biology of ependymomas.Brain pathology (Zurich, Switzerland) · 1997Review
- Cell trafficking through the choroid plexus.Cell adhesion & migrationArticle
- Spinal ectopic choroid plexus papilloma in a cat.JFMS open reportsArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A series of frozen specimens of 18 ependymomas and 7 choroid plexus tumors were examined for their expression of cell adhesion molecules, such as neural cell adhesion molecule (NCAM), its polysialylated isoforms (PSA NCAM), and epithelial (E-) cadherin, and of intermediate filament proteins, such as glial fibrillary acidic protein (GFAP) and cytokeratin, using various monoclonal and polyclonal antibodies. Normal choroid plexus and ependyma were taken as controls. Anti-E-cadherin immunoreactivity was observed on the basolateral part of most adult choroid plexus and benign choroid plexus papilloma cells. However, a small number of atypical papillomas and carcinoma cells showed anti- E-cadherin immunoreactivity throughout their cell surface membrane. NCAM were not expressed by adult choroid plexus and benign papilloma cells. Only a few cells expressed NCAM and PSA NCAM in developing choroid plexus, atypical papillomas and carcinomas. Cytokeratin expression was always observed in choroid plexus and their tumors; GFAP expression was variable from case to case. In contrast, ependymal cells and their tumors never expressed E-cadherin but strongly expressed NCAM. PSA NCAM was found in ependymomas exhibiting anaplastic features. All ependymomas strongly expressed GFAP and a few demonstrated slight expression of cytokeratin. These data suggest that, besides GFAP and cytokeratin, NCAM and E-cadherin are of potential diagnostic value in distinguishing choroid plexus tumors from ependymomas. E-cadherin and NCAM may play a role in the functional organization of normal choroid plexus and ependyma, respectively. In particular, incomplete or irregular anti-E-cadherin expression in choroid plexus tumors and PSA NCAM immunoreativity in ependymomas and choroid plexus tumors correlates with the emergence of anaplastic histological features.
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