Evidence map›Paper›PMID 7754628›Full record

ReviewWorld journal of surgery

Biology of human colon cancer metastasis.

M Gutman, I J Fidler

Abstract readReview
PubMed Publisher
In one paragraph

Review in World journal of surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 133 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Development of a novel model for predicting survival of patients with spine metastasis from colorectal cancer.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2019
    Article
  6. Article
  7. Article
  8. Article
  9. Prognostic risk factors in patients with bone metastasis from colorectal cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Surgical resection for lung metastases from colorectal cancer.Journal of the Korean Society of Coloproctology · 2010
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

M GutmanDepartment of Cell Biology, University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.
I J Fidler
The University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
HUMAN CANCER METASTASIS--BIOLOGY AND TREATMENTR35CA042107 · NCI · UNIVERSITY OF TEXAS MD ANDERSON CAN CTR · PI FIDLER, ISAIAH J · 1987 to 2000
$460k
NCI NIH HHS CA 16672NCI NIH HHS R35 CA42107
6 · The paper itself

Abstract

The process of metastasis is highly selective and favors the survival and growth of a few subpopulations of cells that preexist within a heterogeneous primary neoplasm. To produce metastases, tumor cells must succeed in invasion, embolization, survival in the circulation, arrest in a distant capillary bed, and extravasation into and multiplication in organ parenchyma. The outcome of this process depends on the interaction of metastatic cells with multiple host factors. To assess metastatic potential accurately, it is necessary to orthotopically implant human tumor cells recovered from surgical specimens into nude mice. This orthotopic implantation of tumor cells is invariably associated with trauma to the specific organ of implantation, which is followed by the processes of inflammation and repair. Tissue-specific growth factors may be responsible for stimulation of tumor cells that possess specific surface receptors. Understanding the factors that regulate cancer metastasis should allow for the design of rational therapy.

Indexed as

AnimalsAntineoplastic AgentsCell SurvivalColonic NeoplasmsDisease Models, AnimalHumansMiceMice, NudeNeoplasm InvasivenessNeoplasm MetastasisNeoplasm TransplantationAntineoplastic Agents

Identifiers

PMID7754628
OpenAlexW2078616095

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.