ArticleProceedings of the National Academy of Sciences of the United States of America1995
Pax-6 and lens-specific transcription of the chicken delta 1-crystallin gene.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 105 citations in OpenAlex.
- Multiomics Analysis Reveals Novel Genetic Determinants for Lens Differentiation, Structure, and Transparency.Biomolecules · 2023Review
- Molecular signature for senile and complicated cataracts derived from analysis of sumoylation enzymes and their substrates in human cataract lenses.Aging cell · 2020Article
- A comprehensive spatial-temporal transcriptomic analysis of differentiating nascent mouse lens epithelial and fiber cells.Experimental eye research · 2018Article
- Loss of Sip1 leads to migration defects and retention of ectodermal markers during lens development.Mechanisms of development · 2014Article
- Ocular aldehyde dehydrogenases: protection against ultraviolet damage and maintenance of transparency for vision.Progress in retinal and eye research · 2013Review
- Patterns of gene expression in microarrays and expressed sequence tags from normal and cataractous lenses.Human genomics · 2012Article
- Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- The transcription factor D-Pax2 regulates crystallin production during eye development in Drosophila melanogaster.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- The molecular basis of defective lens development in the Iberian mole.BMC biology · 2008Article
- Genetic and epigenetic mechanisms of gene regulation during lens development.Progress in retinal and eye research · 2007Review
- Crystallization and preliminary X-ray analysis of the Pax6 paired domain bound to the Pax6 gene enhancer.Acta crystallographica. Section F, Structural biology and crystallization communications · 2005Article
- Regulation of gene expression by Pax6 in ocular cells: a case of tissue-preferred expression of crystallins in lens.The International journal of developmental biology · 2004Review
- JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure.Genes & development · 2003Article
- Neural stem cell heterogeneity demonstrated by molecular phenotyping of clonal neurospheres.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Pax6 and SOX2 form a co-DNA-binding partner complex that regulates initiation of lens development.Genes & development · 2001Article
- Antagonistic action of Six3 and Prox1 at the gamma-crystallin promoter.Nucleic acids research · 2001Article
- Dual roles for Pax-6: a transcriptional repressor of lens fiber cell-specific beta-crystallin genes.Molecular and cellular biology · 1998Article
- Overlapping Sp1 and AP2 binding sites in a promoter element of the lens-specific MIP gene.Nucleic acids research · 1998Article
- Pax3 modulates expression of the c-Met receptor during limb muscle development.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Regulation of the murine alpha B-crystallin/small heat shock protein gene in cardiac muscle.Molecular and cellular biology · 1995Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The abundance of delta-crystallin in the chicken eye lens provides an advantageous marker for tissue-specific gene expression during cellular differentiation. The lens-specific expression of the delta 1-crystallin gene is governed by an enhancer in the third intron, which binds a positive (delta EF2) and negative (delta EF1) factor in its core region. Here we show by DNase I footprinting, electrophoretic mobility-shift assays, and cotransfection experiments with the delta 1-promoter/enhancer fused to the chloramphenicol acetyltransferase reporter gene that the delta 1-crystallin enhancer has two adjacent functional Pax-6 binding sites. We also demonstrate by DNase I footprinting that the delta EF1 site can bind the transcription factor USF, raising the possibility that USF may cooperate with Pax-6 in activation of the chicken delta 1- and alpha A-crystallin genes. These data, coupled with our recent demonstration that Pax-6 activates the alpha A-crystallin gene, suggest that Pax-6 may have been used extensively throughout evolution to recruit and express crystallin genes in the lens.
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