ArticleProceedings of the National Academy of Sciences of the United States of America1995
Species-specific metastasis of human tumor cells in the severe combined immunodeficiency mouse engrafted with human tissue.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 69 citations in OpenAlex.
- Advancing small cell lung cancer metastasis research: innovations in preclinical mouse models.Cancer metastasis reviews · 2025Review
- Interferon-Induced Transmembrane Protein 1 (IFITM1) Promotes Distant Metastasis of Small Cell Lung Cancer.International journal of molecular sciences · 2020Article
- Emerging and Established Models of Bone Metastasis.Cancers · 2018Review
- Tissue engineering a surrogate niche for metastatic cancer cells.Biomaterials · 2015Article
- New metastatic model of human small-cell lung cancer by orthotopic transplantation in mice.Cancer science · 2015Article
- A tissue-engineered humanized xenograft model of human breast cancer metastasis to bone.Disease models & mechanisms · 2014Article
- Skeletal metastasis: treatments, mouse models, and the Wnt signaling.Chinese journal of cancer · 2013Review
- A novel animal model for bone metastasis in human lung cancer.Oncology letters · 2012Article
- Unravelling the complexity of metastasis - molecular understanding and targeted therapies.Nature reviews. Cancer · 2011Review
- Article
- Transforming growth factor-beta signaling at the tumor-bone interface promotes mammary tumor growth and osteoclast activation.Cancer science · 2009Article
- Article
- Article
- Persistence of human vascular endothelium in experimental human prostate cancer bone tumors.Clinical & experimental metastasis · 2000Article
- Technical considerations for studying cancer metastasis in vivo.Clinical & experimental metastasis · 1997Review
- Analysis of IL-2 receptor expression and of the biological effects of IL-2 gene transfection in small-cell lung cancer.British journal of cancer · 1996Article
- A novel SCID mouse model for studying spontaneous metastasis of human lung cancer to human tissue.Japanese journal of cancer research : Gann · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have attempted to model human metastatic disease by implanting human target organs into the immunodeficient C.B-17 scid/scid (severe combined immunodeficiency; SCID) mouse, creating SCID-hu mice. Preferential metastasis to implants of human fetal lung and human fetal bone marrow occurred after i.v. injection of human small cell lung cancer (SCLC) cells into SCID-hu mice; the homologous mouse organs were spared. Clinically more aggressive variant SCLC cells metastasized more efficiently to human fetal lung implants than did cells from classic SCLC. Metastasis of variant SCLC to human fetal bone marrow was enhanced in SCID-hu mice exposed to gamma-irradiation or to interleukin 1 alpha. These data indicate that the SCID-hu mice may provide a model in which to study species- and tissue-specific steps of the human metastatic process.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.