ArticleProceedings of the National Academy of Sciences of the United States of America1995
Anterior axis duplication in Xenopus induced by the over-expression of the cadherin-binding protein plakoglobin.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 163 citations in OpenAlex.
- Two is a Crowd: Two is a Crowd: On the Enigmatic Etiopathogenesis of Conjoined Twinning.Clinical anatomy (New York, N.Y.) · 2019Review
- Beyond cell-cell adhesion: Plakoglobin and the regulation of tumorigenesis and metastasis.Oncotarget · 2017Review
- Beyond β-catenin: prospects for a larger catenin network in the nucleus.Nature reviews. Molecular cell biology · 2016Review
- Nuclear signaling from cadherin adhesion complexes.Current topics in developmental biology · 2015Review
- Chibby functions in Xenopus ciliary assembly, embryonic development, and the regulation of gene expression.Developmental biology · 2014Article
- Looking beyond the Wnt pathway for the deep nature of β-catenin.EMBO reports · 2013Review
- Wnt/beta-catenin signaling and small molecule inhibitors.Current pharmaceutical design · 2013Review
- Ectopic γ-catenin expression partially mimics the effects of stabilized β-catenin on embryonic stem cell differentiation.PloS one · 2013Article
- Signaling from the adherens junction.Sub-cellular biochemistry · 2012Review
- Plakoglobin: role in tumorigenesis and metastasis.International journal of cell biology · 2012Article
- Desmosomes: new perpetrators in tumour suppression.Nature reviews. Cancer · 2011Review
- Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members.Journal of cell science · 2010Article
- Desmosomes: a role in cancer?British journal of cancer · 2007Review
- SOX7 and SOX18 are essential for cardiogenesis in Xenopus.Developmental dynamics : an official publication of the American Association of Anatomists · 2005Article
- beta-catenin-dependent and -independent effects of DeltaN-plakoglobin on epidermal growth and differentiation.Molecular and cellular biology · 2004Article
- Plakoglobin is a new target gene of histone deacetylase in human fibrosarcoma HT1080 cells.Oncogene · 2004Article
- Beta-catenin is dispensable for hematopoiesis and lymphopoiesis.The Journal of experimental medicine · 2004Article
- gamma-Catenin expression is reduced or absent in a subset of human lung cancers and re-expression inhibits transformed cell growth.Oncogene · 2002Article
- Plakoglobin is required for maintenance of the cortical actin skeleton in early Xenopus embryos and for cdc42-mediated wound healing.The Journal of cell biology · 2002Article
- Nr-CAM is a target gene of the beta-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis.Genes & development · 2002Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plakoglobin interacts with both classical and desmosomal cadherins. It is closely related to Drosophila aramadillo (arm) gene product; arm acts in the wingless (wg)-signaling pathway to establish segment polarity. In Xenopus, homologs of wg--i.e., wnts, can produce anterior axis duplications by inducing dorsal mesoderm. Studies in Drosophila suggest that wnt acts by increasing the level of cytoplasmic armadillo protein (arm). To test whether simply increasing the level of plakoglobin mimics the effects of exogenous wnts in Xenopus, we injected fertilized eggs with RNA encoding an epitope-tagged form of plakoglobin; this induced both early radial gastrulation and anterior axis duplication. Exogenous plakoglobin accumulates in the nuclei of embryonic cells. Plakoglobin binds to the tail domain of the desmosomal cadherin desmoglein 1. When RNA encoding the tail domain of desmoglein was coinjected with plakoglobin RNA, both the dorsalizing effect and nuclear accumulation of plakoglobin were suppressed. Mutational analysis indicates that the central arm repeat region of plakoglobin is sufficient to induce axis duplication and that this polypeptide accumulates in the nuclei of embryonic cells. These data show that increased plakoglobin levels can, by themselves, generate the intracellular signals involved in the specification of dorsal mesoderm.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.