ArticleProceedings of the National Academy of Sciences of the United States of America1995
Primary structure of hepatocyte nuclear factor/forkhead homologue 4 and characterization of gene expression in the developing respiratory and reproductive epithelium.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 123 citations in OpenAlex.
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- Cilia and transcription: a mini review.Frontiers in cell and developmental biology · 2025Review
- Novel dominant-negativeTranslational pediatrics · 2023Article
- Congenital heart defects caused by FOXJ1.Human molecular genetics · 2023Article
- Gene activation of metazoan Fox transcription factors at the onset of metamorphosis in the marine demosponge Amphimedon queenslandica.Development, growth & differentiation · 2022Article
- Autosomal dominant variants in FOXJ1 causing primary ciliary dyskinesia in two patients with obstructive hydrocephalus.Molecular genetics & genomic medicine · 2021Article
- De Novo Mutations in FOXJ1 Result in a Motile Ciliopathy with Hydrocephalus and Randomization of Left/Right Body Asymmetry.American journal of human genetics · 2019Article
- A Subset of Olfactory Sensory Neurons Express Forkhead Box J1-Driven eGFP.Chemical senses · 2019Article
- Conditional ablation of the RFX4 isoform 1 transcription factor: Allele dosage effects on brain phenotype.PloS one · 2018Article
- GemC1 controls multiciliogenesis in the airway epithelium.EMBO reports · 2016Article
- Both ciliary and non-ciliary functions of Foxj1a confer Wnt/β-catenin signaling in zebrafish left-right patterning.Biology open · 2015Article
- Forkhead box J1 expression is upregulated and correlated with prognosis in patients with clear cell renal cell carcinoma.Oncology letters · 2015Article
- Increased susceptibility to pulmonary Pseudomonas infection in Splunc1 knockout mice.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Changes in the Foxj1 expression of Schwann cells after sciatic nerve crush.Journal of molecular histology · 2013Article
- RFX3 modulation of FOXJ1 regulation of cilia genes in the human airway epithelium.Respiratory research · 2013Article
- Article
- Lung epithelial healing: a modified seed and soil concept.Proceedings of the American Thoracic Society · 2012Article
- Increased expression of Foxj1 after traumatic brain injury.Journal of molecular neuroscience : MN · 2011Article
- Hierarchical interactions of homeodomain and forkhead transcription factors in regulating odontogenic gene expression.The Journal of biological chemistry · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Members of the winged helix/forkhead family of transcription factors are believed to play a role in cell-specific gene expression. A cDNA encoding a member of this family of proteins, termed hepatocyte nuclear factor/forkhead homologue 4 (HFH-4), has been isolated from rat lung and rat testis cDNA libraries. This cDNA contains an open reading frame of 421 amino acids with a conserved DNA binding domain and several potential transactivating regions. During murine lung development, a single species of HFH-4-specific transcript (2.4 kb long) is first detected precisely at the start of the late pseudoglandular stage (embryonic day 14.5) and, by in situ hybridization, is specifically localized to the proximal pulmonary epithelium. The unique temporal and spatial pattern of HFH-4 gene expression in the developing lung defines this protein as a marker for the initiation of bronchial epithelial cell differentiation and suggests that it may play an important role in cell fate determination during lung development. In addition to expression in the pulmonary epithelium, RNA blot analysis reveals 2.4-kb HFH-4 transcripts in the testis and oviduct. By using mice with genetic defects in spermatogenesis, HFH-4 expression in the testis is found to be associated with the appearance of haploid germ cells and in situ hybridization studies indicate that HFH-4 expression is confined to stages I-VII of spermatogenesis. This pattern of HFH-4 gene expression during the early stages of differentiation of haploid germ cells suggests that HFH-4 may play a role in regulating stage-specific gene expression and cell-fate determination during lung development and in spermatogenesis.
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