ArticleProceedings of the National Academy of Sciences of the United States of America1995
Redundant 3' end-forming signals for the yeast CYC1 mRNA.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- The functionality of telomerase depends on CPF-CF induced 3'end processing of its RNA component TLC1 and a novel Nrd1-Nab3 surveillance mechanism.Nucleic acids research · 2025Article
- Surveillance of 3' mRNA cleavage during transcription termination requires CF IB/Hrp1.Nucleic acids research · 2023Article
- Deep learning of the regulatory grammar of yeast 5' untranslated regions from 500,000 random sequences.Genome research · 2017Article
- Global mapping of DNA conformational flexibility on Saccharomyces cerevisiae.PLoS computational biology · 2015Article
- In silico analysis of 3'-end-processing signals in Aspergillus oryzae using expressed sequence tags and genomic sequencing data.DNA research : an international journal for rapid publication of reports on genes and genomes · 2011Article
- Coupled RNA polymerase II transcription and 3' end formation with yeast whole-cell extracts.RNA (New York, N.Y.) · 2010Article
- Polyadenylation site choice in yeast is affected by competition between Npl3 and polyadenylation factor CFI.RNA (New York, N.Y.) · 2007Article
- Functional dissection of the zinc finger and flanking domains of the Yth1 cleavage/polyadenylation factor.Nucleic acids research · 2003Article
- Probabilistic prediction of Saccharomyces cerevisiae mRNA 3'-processing sites.Nucleic acids research · 2002Article
- Statistical analysis of yeast genomic downstream sequences reveals putative polyadenylation signals.Nucleic acids research · 2000Article
- Formation of mRNA 3' ends in eukaryotes: mechanism, regulation, and interrelationships with other steps in mRNA synthesis.Microbiology and molecular biology reviews : MMBR · 1999Review
- Transcription termination downstream of the Saccharomyces cerevisiae FBP1 [changed from FPB1] poly(A) site does not depend on efficient 3'end processing.RNA (New York, N.Y.) · 1998Article
- Sequence requirements of the bidirectional yeast TRP4 mRNA 3'-end formation signal.Nucleic acids research · 1997Article
- RNA polymerase III defects suppress a conditional-lethal poly(A) polymerase mutation in Saccharomyces cerevisiae.Genetics · 1996Article
- Signals sufficient for 3'-end formation of yeast mRNA.Molecular and cellular biology · 1996Article
- 3'-end-forming signals of yeast mRNA.Molecular and cellular biology · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The cyc1-512 mutation is a 38-bp deletion in the 3' untranslated region of the CYC1 gene, which encodes iso-1-cytochrome c in Saccharomyces cerevisiae. This deletion caused a 90% reduction in the levels of the CYC1 mRNA and protein because of the absence of the normal 3' end-forming signal. Although the 3' end-forming signal was not defined by previous analyses, we report that concomitant alteration by base-pair substitution of three 3' end-forming signals within and adjacent to the 38-bp region produced the same phenotype as the cyc1-512 mutation. Furthermore, these signals appear to be related to the previously identified 3' end-forming signal TATATA. A computer analysis revealed that TATATA and related sequences were present in the majority of 3' untranslated regions of yeast genes. Although TATATA may be the strongest and most frequently used signal in yeast genes, the CYC1+ gene concomitantly employed the weaker signals TT-TATA, TATGTT, and TATTTA, resulting in a strong signal.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.