ArticleMolecular & general genetics : MGG1995
Pathway analysis of radiation-sensitive meiotic mutants of Coprinus cinereus.
Article in Molecular & general genetics : MGG, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Discovery of microRNA-like RNAs during early fruiting body development in the model mushroom Coprinopsis cinerea.PloS one · 2018Article
- A mutation in the FHA domain of Coprinus cinereus Nbs1 Leads to Spo11-independent meiotic recombination and chromosome segregation.G3 (Bethesda, Md.) · 2013Article
- 5'-Serial Analysis of Gene Expression studies reveal a transcriptomic switch during fruiting body development in Coprinopsis cinerea.BMC genomics · 2013Article
- Global gene expression in Coprinopsis cinerea meiotic mutants reflects checkpoint arrest.G3 (Bethesda, Md.) · 2012Article
- Analysis of the Basidiomycete Coprinopsis cinerea reveals conservation of the core meiotic expression program over half a billion years of evolution.PLoS genetics · 2010Article
- Meiotic localization of Mre11 and Rad50 in wild type, spo11-1, and MRN complex mutants of Coprinus cinereus.Chromosoma · 2009Article
- Article
- Functional links between Drosophila Nipped-B and cohesin in somatic and meiotic cells.Chromosoma · 2008Article
- The Coprinus cinereus adherin Rad9 functions in Mre11-dependent DNA repair, meiotic sister-chromatid cohesion, and meiotic homolog pairing.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Life history and developmental processes in the basidiomycete Coprinus cinereus.Microbiology and molecular biology reviews : MMBR · 2000Review
- Multiple roles of Spo11 in meiotic chromosome behavior.The EMBO journal · 2000Article
- An mre11 mutant of Coprinus cinereus has defects in meiotic chromosome pairing, condensation and synapsis.Genetics · 2000Article
- Article
- The rad9 gene of Coprinus cinereus encodes a proline-rich protein required for meiotic chromosome condensation and synapsis.Genetics · 1996Article
- Chromosome dynamics in rad12 mutants of Coprinus cinereus.Chromosoma · 1995Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We have isolated 37 radiation-sensitive mutants of the basidiomycete Coprinus cinereus. Each mutation is recessive, and the collection defines at least ten complementation groups for survival of gamma irradiation. Four complementation groups define the genes rad3, rad9, rad11 and rad12, which are required both for survival of gamma irradiation and for meiosis. Mutants in each of these four groups fail to complete meiosis and produce mushrooms with greatly reduced numbers of viable spores. Propidium iodide staining of meiotic nuclei showed a characteristic terminal appearance for each mutant: few cells of any of the meiotic mutants progress beyond prophase I, and both condensation and fragmentation or dispersal of meiotic chromatin are frequently observed. Scanning electron micrographs showed that the meiotic mutants make varying numbers (0-6) of basidiospore initials and that few of these initials develop into mature spores. When initials are present they are always symmetrically arrayed on the basidium, regardless of initial number. In quantitative measurements of gamma ray sensitivity, double mutants of every tested combination of rad3, rad9, rad11 and rad12 consistently showed the same gamma ray sensitivity as the more sensitive single mutant parent of the cross. Therefore, these four genes are in the same pathway for the repair of gamma radiation damage, and this pathway also represents one or more functions essential for meiosis.
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