ArticleJournal of neurology1995
Stiff man syndrome: neurophysiological findings in eight patients.
Article in Journal of neurology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 88 citations in OpenAlex.
- The role of IVIg in the treatment of patients with stiff person syndrome and other neurological diseases associated with anti-GAD antibodies.Journal of neurology · 2005Trial
- Exteroceptive Reflexes in Stiff Person Syndrome, Other Neurological Conditions and Healthy Controls.Movement disorders clinical practice · 2026Article
- Neurophysiological Insights into the Pathophysiology of Stiff-Person Spectrum Disorders.Movement disorders clinical practice · 2025Review
- STIFF PERSON SYNDROME-MANAGING A RARE AUTOIMMUNE DISORDER IN A LOW RESOURCE SETTING: A CASE REPORT.Annals of Ibadan postgraduate medicine · 2025Article
- Stiff-person syndrome and related disorders - diagnosis, mechanisms and therapies.Nature reviews. Neurology · 2024Review
- The computational neurology of movement under active inference.Brain : a journal of neurology · 2021Article
- [Stiff man syndrome and variants].Der Nervenarzt · 2013Article
- Autoimmune stiff person syndrome and related myelopathies: understanding of electrophysiological and immunological processes.Muscle & nerve · 2012Review
- An uncommon paraneoplastic Ri-positive opsoclonus-myoclonus-like syndrome and stiff-person syndrome with elevated glutamate/GABA ratio in the cerebrospinal fluid after breast cancer.Journal of neurology · 2010Article
- Effects of immunotherapy on motor cortex excitability in Stiff Person Syndrome.Journal of neurology · 2010Article
- Stiff person syndrome: advances in pathogenesis and therapeutic interventions.Current treatment options in neurology · 2009Article
- Advances in the pathogenesis and treatment of patients with stiff person syndrome.Current neurology and neuroscience reports · 2008Review
- Role of IVIg in autoimmune, neuroinflammatory and neurodegenerative disorders of the central nervous system: present and future prospects.Journal of neurology · 2006Review
- Hyperekplexia and stiff-man syndrome: abnormal brainstem reflexes suggest a physiological relationship.Journal of neurology, neurosurgery, and psychiatry · 2004Article
- Stiff man syndrome.CNS drugs · 2001Review
- The stiff leg syndrome.Journal of neurology, neurosurgery, and psychiatry · 1997Article
- Electrophysiological evaluation of the stiff-man syndrome: further data.Journal of neurology · 1996Article
- Axial Dystonia Mimicking Stiff Person Syndrome.Movement disorders clinical practiceArticle
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
The neurophysiological findings in eight patients with the stiff man syndrome (SMS), including four of six tested with autoantibodies against glutamic acid decarboxylase, are presented. Neurophysiological findings did not make it possible to discriminate between patients with and those without autoimmunity against GABAergic neurons. Investigation of mono- and polysynaptic reflexes revealed abnormal results in a variable number of SMS patients, the abnormalities largely corresponding to those seen in spastic paresis. A stereotyped motor response to electrical stimulation of peripheral nerves was recorded from the trunk muscles of all patients investigated. This response was termed spasmodic reflex myoclonus and consisted of a sequence of 1-3 synchronous myoclonic bursts, 60-70 ms after median nerve stimulation, followed by a tonic decrescendo activity over a number of seconds. The recruitment order of muscles along the neuraxis in spasmodic reflex myoclonus suggested that the latter was generated in the spinal cord and conveyed via propriospinal tracts. It is thought that spasmodic reflex myoclonus may serve not only as a diagnostic tool, but also as a key to understanding some aspects of the pathophysiology of both spasms and stiffness in SMS. It is speculated that stiffness is a fragment of spasms, both being generated by common neuronal mechanisms tentatively ascribed to interneurons in the spinal grey matter.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.