ArticleJournal of clinical microbiology1995
Investigation of Candida albicans transmission in a surgical intensive care unit cluster by using genomic DNA typing methods.
Article in Journal of clinical microbiology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Candida albicans Carriage in Children with Severe Early Childhood Caries (S-ECC) and Maternal Relatedness.PloS one · 2016Article
- Genetic diversity among Korean Candida albicans bloodstream isolates: assessment by multilocus sequence typing and restriction endonuclease analysis of genomic DNA by use of BssHII.Journal of clinical microbiology · 2011Article
- Genetic relationships between Candida albicans strains isolated from dental plaque, trachea, and bronchoalveolar lavage fluid from mechanically ventilated intensive care unit patients.Journal of oral microbiology · 2011Article
- Kodamaea ohmeri isolates from patients in a university hospital: identification, antifungal susceptibility, and pulsed-field gel electrophoresis analysis.Journal of clinical microbiology · 2007Article
- Fecal fungal flora of pediatric healthy volunteers and immunosuppressed patients.Mycopathologia · 2005Article
- Molecular subtyping of clinical isolates of Candida albicans and identification of Candida dubliniensis Malaysia.Mycopathologia · 2005Article
- Persistence of oropharyngeal Candida albicans strains with reduced susceptibilities to fluconazole among human immunodeficiency virus-seropositive children and adults in a long-term care facility.Journal of clinical microbiology · 2003Article
- The ins and outs of DNA fingerprinting the infectious fungi.Clinical microbiology reviews · 2000Review
- Trends in antifungal use and epidemiology of nosocomial yeast infections in a university hospital.Journal of clinical microbiology · 1999Article
- Parity among the randomly amplified polymorphic DNA method, multilocus enzyme electrophoresis, and Southern blot hybridization with the moderately repetitive DNA probe Ca3 for fingerprinting Candida albicans.Journal of clinical microbiology · 1997Article
- Antifungal prophylaxis during neutropenia and immunodeficiency.Clinical microbiology reviews · 1997Review
- Variations in fluconazole susceptibility and DNA subtyping of multiple Candida albicans colonies from patients with AIDS and oral candidiasis suffering one or more episodes of infection.Journal of clinical microbiology · 1997Article
- Comparative analysis of genetic variability among Candida albicans isolates from different geographic locales by three genotypic methods.Journal of clinical microbiology · 1997Article
- Strain variation among and antifungal susceptibilities of isolates of Candida krusei.Journal of clinical microbiology · 1996Article
- Contribution of molecular typing methods and antifungal susceptibility testing to the study of a candidemia cluster in a burn care unit.Journal of clinical microbiology · 1995Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An apparent outbreak of serious Candida albicans infections (n = 6) occurred in a surgical intensive care unit over a 4-week period. Four patients developed C. albicans bloodstream infections. An additional patient developed catheter-related C. albicans infection; the sixth patient developed an infection of cerebrospinal fluid. C. albicans was isolated from the hands of five health care workers (17%) and the throat of one health care worker (3%) during the outbreak investigation. Karyotyping and restriction endonuclease analysis of genomic DNA with BssHII of 23 C. albicans isolates from patients and the 6 health care worker isolates revealed 9 and 12 different patterns, respectively. Three of six patients appeared to be infected with the same C. albicans strain (two bloodstream infections and one cerebrospinal fluid infection). The hands of a health care worker were colonized with strain that appeared identical to an isolate from a patient prior to infection of the patient. However, restriction endonuclease analysis with SfiI found differences among the isolates determined to be identical by the other two methods. Karyotyping alone does not appear to be sufficient to differentiate between outbreak and control isolates. Restriction endonuclease analysis typing may be a more sensitive method than karyotyping alone in the investigation of a cluster of C. albicans infections. Furthermore, the use of more than one restriction enzyme may be necessary for optimal strain discrimination in restriction endonuclease analysis of genomic DNA.
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