ArticleImmunology1995
T-cell responses to orally administered antigens. Study of the kinetics of lymphokine production after single and multiple feeding.
Article in Immunology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 37 citations in OpenAlex.
- Changes in lamina propria dendritic cells on the oral administration of exogenous protein antigens during weaning.Cytotechnology · 2012Article
- Induction of mucosal tolerance in SLE: a sniff or a sip away from ameliorating lupus?Clinical immunology (Orlando, Fla.) · 2009Review
- Oral tolerance in T cells is accompanied by induction of effector function in lymphoid organs after systemic immunization.Infection and immunity · 2004Article
- Feeding NOD mice with pig splenocytes induces transferable mechanisms that modulate cellular and humoral xenogeneic reactions against pig spleen or islet cells.Clinical and experimental immunology · 2002Article
- Lamina propria lymphocytes produce interferon-gamma and develop suppressor activity in response to lactoglobulin.Digestive diseases and sciences · 2001Article
- Th2 polarization enhanced by oral administration of higher doses of antigen.Cytotechnology · 2000Article
- Low dose of orally administered antigen down-regulates the T helper type 2-response in a murine model of dust mite hypersensitivity.Immunology · 1999Article
- Effect of multiple antigenic exposures in the gut on oral tolerance and induction of antibacterial systemic immunity.Infection and immunity · 1999Article
- Immunoglobulin E suppression and cytokine modulation in mice orally tolerized to beta-lactoglobulin.Immunology · 1999Article
- Immunologic tolerance to myelin basic protein decreases stroke size after transient focal cerebral ischemia.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Interferon-gamma receptor-deficient mice exhibit impaired gut mucosal immune responses but intact oral tolerance.Immunology · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mice fed a protein antigen develop a phenomenon called oral tolerance which is defined classically by the inability to respond to a parenteral challenge with the same antigen. In a recent report we showed that antigen-reactive T cells are not depleted following the development of oral tolerance to the soluble antigen ovalbumin (OVA). Instead mice remain highly sensitized so OVA-reactive T cells can be detected in the mesenteric lymph nodes (MLN), Peyer's patches and spleen. In the present study we show that OVA-specific T cells become sensitized in the MLN within 24 hr of feeding and that lymphokine responses peak 48-96 hr after feeding. T cells produced large amounts of granulocyte-macrophage colony-stimulating factor (GM-CSF) and interferon-gamma (IFN-gamma) but no interleukin-2 (IL-2) following activation in vitro. Responsiveness as measured by GM-CSF declined by days 8-11 while the ability to stimulate IFN-gamma secretion was more persistent. It was found in experiments with repeated feeding, 1 week apart, that the T-cell responsiveness was restimulated after each feed and that the magnitude and duration of the IFN-gamma or GM-CSF responses were almost identical to primary, even after 10 feeds.
Indexed as
Identifiers
7751007PMC1415102W61923048What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.