ArticleThe American journal of pathology1995
Apoptosis participates in cellularity regulation during rat aortic intimal thickening.
Article in The American journal of pathology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Regulated vascular smooth muscle cell death in vascular diseases.Cell proliferation · 2024Review
- Article
- The Reducing Effects of Pyrogallol-Phloroglucinol-6,6-Bieckol on High-Fat Diet-Induced Pyroptosis in Endothelial and Vascular Smooth Muscle Cells of Mice Aortas.Marine drugs · 2020Article
- An update on clonality: what smooth muscle cell type makes up the atherosclerotic plaque?F1000Research · 2018Review
- Overexpression of mimecan in human aortic smooth muscle cells inhibits cell proliferation and enhances apoptosis and migration.Experimental and therapeutic medicine · 2015Article
- A small molecule PAI-1 functional inhibitor attenuates neointimal hyperplasia and vascular smooth muscle cell survival by promoting PAI-1 cleavage.Cellular signalling · 2015Article
- A Novel Approach against Vascular Intimal Hyperplasia Through the Suppression of Girdin.Annals of vascular diseases · 2015Review
- Small Molecule PAI-1 Functional Inhibitor Attenuates Vascular Smooth Muscle Cell Migration and Survival: Implications for the Therapy of Vascular Disease.New horizons in translational medicine · 2014Article
- TGF-β/Smad3 inhibit vascular smooth muscle cell apoptosis through an autocrine signaling mechanism involving VEGF-A.Cell death & disease · 2014Article
- Vinpocetine attenuates neointimal hyperplasia in diabetic rat carotid arteries after balloon injury.PloS one · 2014Article
- Sortilin expression is essential for pro-nerve growth factor-induced apoptosis of rat vascular smooth muscle cells.PloS one · 2014Article
- Type VIII collagen mediates vessel wall remodeling after arterial injury and fibrous cap formation in atherosclerosis.The American journal of pathology · 2013Article
- Role of the phosphatase PTEN in early vascular remodeling.PloS one · 2013Article
- Transforming growth factor-β and atherosclerosis: interwoven atherogenic and atheroprotective aspects.Cell and tissue research · 2012Review
- Receptor interacting protein 3 suppresses vascular smooth muscle cell growth by inhibition of the phosphoinositide 3-kinase-Akt axis.The Journal of biological chemistry · 2010Article
- Endogenous testosterone attenuates neointima formation after moderate coronary balloon injury in male swine.Cardiovascular research · 2009Article
- Inflammation in the vascular bed: importance of vitamin C.Pharmacology & therapeutics · 2008Review
- Role of statins in cerebral vasospasm.Acta neurochirurgica. Supplement · 2008Article
- P2 receptors in atherosclerosis and postangioplasty restenosis.Purinergic signalling · 2007Article
- P2 receptors in atherosclerosis and postangioplasty restenosis.Purinergic signalling · 2006Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intimal thickening induced after endothelial denudation of rat aorta is though to be due to migration and proliferation of smooth muscle cells (SMC). When the reendothelialization is achieved, intimal thickening shows an important decrease in cellularity. Using in situ end labeling of fragmented DNA and electron microscopy, we show that this remodeling is accompanied by apoptosis of SMC. The number of apoptotic SMC becomes important 15 days after endothelial injury and reaches a maximum at 20 days; at 45 days the intimal thickening is reendothelialized and no more apoptotic SMC are detected. Apoptotic SMC show nuclear and cytoplasmic condensation as well as cytoplasmic vacuolization. Our results indicate that apoptosis is an important mechanism in the regulation of intimal thickening evolution.
Indexed as
Identifiers
7747800PMC1869281What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.