Evidence map›Paper›PMID 7745745›Full record

ArticleJournal of virology1995

Characterization of cytotoxic cells from reovirus-infected SCID mice: activated cells express natural killer- and lymphokine-activated killer-like activity but fail to clear infection.

J Taterka, J J Cebra, D H Rubin

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

J TaterkaDepartment of Medicine, Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA.
J J Cebra
D H Rubin
Veterans Health Administration · US

Funding

UNIVERSITY OF PENNSYLVANIA TRAINING IN GASTROENTEROLOGYT32DK007066 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI JONATHAN P KATZ · 1986 to 2026
$11.7M
REOVIRUSES AS PROBES OF GUT MUCOSAL T-CELL RESPONSER01AI023970 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CEBRA, JOHN J · 1986 to 2001
$298k
NIAID NIH HHS AI-23970NIDDK NIH HHS T32-DK-07066
6 · The paper itself

Abstract

Severe combined immune deficient (SCID) mice infected orally with reovirus type 1/L die of hepatitis. Leukocytes bearing the cell surface antigens Thy-1.2 and asialoGM-1 (AsGM1) accumulate in the livers of infected animals. These cells display lytic activity toward natural killer-sensitive (YAC-1) and -resistant (P815) cell lines and murine hepatoma line Hepa 1/A1. Although these cells have the capacity to lyse infected hepatoma targets, they cannot clear the virus.

Indexed as

AnimalsCytotoxicity, ImmunologicKiller Cells, Lymphokine-ActivatedKiller Cells, NaturalLiver DiseasesMiceMice, Inbred BALB CMice, SCIDReoviridae Infections

Identifiers

PMID7745745
PMCPMC189116
OpenAlexW2125402946

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.