ArticleJournal of virology1995
Human MxA protein inhibits tick-borne Thogoto virus but not Dhori virus.
Article in Journal of virology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
53 citing papers in PubMed, 139 citations in OpenAlex.
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- Synergistic antiviral activity of Lactobacillus acidophilus and Glycyrrhiza glabra against Herpes Simplex-1 Virus (HSV-1) and Vesicular Stomatitis Virus (VSV): experimental and In Silico insights.BMC microbiology · 2023Article
- The Antiviral Activity of Equine Mx1 against Thogoto Virus Is Determined by the Molecular Structure of Its Viral Specificity Region.Journal of virology · 2023Article
- Prevalence of Bourbon and Heartland viruses in field collected ticks at an environmental field station in St. Louis County, Missouri, USA.Ticks and tick-borne diseases · 2023Article
- Tick-transmitted thogotovirus gains high virulence by a single MxA escape mutation in the viral nucleoprotein.PLoS pathogens · 2020Article
- Bourbon Virus in Wild and Domestic Animals, Missouri, USA, 2012-2013.Emerging infectious diseases · 2019Article
- Evolution and Antiviral Specificities of Interferon-Induced Mx Proteins of Bats against Ebola, Influenza, and Other RNA Viruses.Journal of virology · 2017Article
- In vivo evasion of MxA by avian influenza viruses requires human signature in the viral nucleoprotein.The Journal of experimental medicine · 2017Article
- Vaccinia virus and Cowpox virus are not susceptible to the interferon-induced antiviral protein MxA.PloS one · 2017Article
- Molecular cloning, polymorphism, and functional activity of the bovine and water buffaloSpringerPlus · 2016Article
- MxB Is Not Responsible for the Blocking of HIV-1 Infection Observed in Alpha Interferon-Treated Cells.Journal of virology · 2015Article
- Restriction of HIV-1 Requires the N-Terminal Region of MxB as a Capsid-Binding Motif but Not as a Nuclear Localization Signal.Journal of virology · 2015Article
- Role of nucleotide binding and GTPase domain dimerization in dynamin-like myxovirus resistance protein A for GTPase activation and antiviral activity.The Journal of biological chemistry · 2015Article
- Contribution of MxB oligomerization to HIV-1 capsid binding and restriction.Journal of virology · 2015Article
- MxB binds to the HIV-1 core and prevents the uncoating process of HIV-1.Retrovirology · 2014Article
- Mx proteins: antiviral gatekeepers that restrain the uninvited.Microbiology and molecular biology reviews : MMBR · 2013Review
- The myxovirus resistance A (MxA) gene -88G>T single nucleotide polymorphism is associated with prostate cancer.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2013Article
- Antiviral specificity of the Solea senegalensis Mx protein constitutively expressed in CHSE-214 cells.Marine biotechnology (New York, N.Y.) · 2013Article
- Myxovirus resistance gene A (MxA) expression suppresses influenza A virus replication in alpha interferon-treated primate cells.Journal of virology · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thogoto and Dhori viruses are tick-borne orthomyxoviruses infecting humans and livestock in Africa, Asia, and Europe. Here, we show that human MxA protein is an efficient inhibitor of Thogoto virus but is inactive against Dhori virus. When expressed in the cytoplasm of stably transfected cell lines, MxA protein interfered with the accumulation of Thogoto viral RNA and proteins. Likewise, MxA(R645), a mutant MxA protein known to be active against influenza virus but inactive against vesicular stomatitis virus, was equally efficient in blocking Thogoto virus growth. Hence, a common antiviral mechanism that is distinct from the antiviral action against vesicular stomatitis virus may operate against both influenza virus and Thogoto virus. When moved to the nucleus with the help of a foreign nuclear transport signal, MxA(R645) remained active against Thogoto virus, indicating that a nuclear step of virus replication was inhibited. In contrast, Dhori virus was not affected by wild-type or mutant MxA protein, indicating substantial differences between these two tick-transmitted orthomyxoviruses. Human MxB protein had no antiviral activity against either virus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.