ArticleJournal of virology1995
Nuclear localization and transcriptional activation activities of truncated versions of the immediate-early gene product of equine herpesvirus 1.
Article in Journal of virology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Interferon Gamma Inhibits Equine Herpesvirus 1 Replication in a Cell Line-Dependent Manner.Pathogens (Basel, Switzerland) · 2021Article
- Intranasal treatment with CpG-B oligodeoxynucleotides protects CBA mice from lethal equine herpesvirus 1 challenge by an innate immune response.Antiviral research · 2019Article
- Decreased expression of the immediate early protein, ICP4, by deletion of the tegument protein VP22 of equine herpesvirus type 1.The Journal of veterinary medical science · 2018Article
- Functional Characterization of the Serine-Rich Tract of Varicella-Zoster Virus IE62.Journal of virology · 2016Article
- Full trans-activation mediated by the immediate-early protein of equine herpesvirus 1 requires a consensus TATA box, but not its cognate binding sequence.Virus research · 2016Article
- Article
- Article
- The unique IR2 protein of equine herpesvirus 1 negatively regulates viral gene expression.Journal of virology · 2006Article
- The alpha-TIF (VP16) homologue (ETIF) of equine herpesvirus 1 is essential for secondary envelopment and virus egress.Journal of virology · 2006Article
- Initial characterization of 17 viruses harboring mutant forms of the immediate-early gene of equine herpesvirus 1.Virus genes · 2005Article
- A negative regulatory element (base pairs -204 to -177) of the EICP0 promoter of equine herpesvirus 1 abolishes the EICP0 protein's trans-activation of its own promoter.Journal of virology · 2004Article
- Interaction of the equine herpesvirus 1 EICP0 protein with the immediate-early (IE) protein, TFIIB, and TBP may mediate the antagonism between the IE and EICP0 proteins.Journal of virology · 2003Article
- Identification of a motif in the C terminus of herpes simplex virus regulatory protein ICP4 that contributes to activation of transcription.Journal of virology · 2002Article
- Mapping the sequences that mediate interaction of the equine herpesvirus 1 immediate-early protein and human TFIIB.Journal of virology · 2001Article
- Characterization of the trans-activation properties of equine herpesvirus 1 EICP0 protein.Journal of virology · 2000Article
- The EICP22 protein of equine herpesvirus 1 physically interacts with the immediate-early protein and with itself to form dimers and higher-order complexes.Journal of virology · 2000Article
- The ICP0 protein of equine herpesvirus 1 is an early protein that independently transactivates expression of all classes of viral promoters.Journal of virology · 1997Article
- The ICP22 protein of equine herpesvirus 1 cooperates with the IE protein to regulate viral gene expression.Journal of virology · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The equine herpesvirus 1 (EHV-1) immediate-early (IE) gene product encodes a nuclear regulatory protein capable of negatively autoregulating its own promoter, transactivating representative EHV-1 early promoters, and acting in a concerted fashion with accessory EHV-1 regulatory factors to transactivate EHV-1 late promoters. To identify IE amino acid sequences involved in nuclear localization and to examine the contribution of C-terminal portions of the IE polypeptide to transactivation, vectors that express various carboxyterminally truncated IE polypeptides were constructed. It is demonstrated that amino acids 963 through 970 of the 1,487-amino-acid IE protein are required for efficient localization of the truncated IE polypeptides to the nuclei of transfected cells. In addition, it is demonstrated that the first 970 amino acids of the IE gene product are sufficient to transactivate the EHV-1 thymidine kinase promoter to significant levels (i.e., approximately 40% of the level of wild-type activation).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.