ArticleJournal of virology1995
Nuclear export of the human immunodeficiency virus type 1 nucleocytoplasmic shuttle protein Rev is mediated by its activation domain and is blocked by transdominant negative mutants.
Article in Journal of virology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Human Retrovirus Genomic RNA Packaging.Viruses · 2022Review
- Inhibitory Effects of HIV-2 Vpx on Replication of HIV-1.Journal of virology · 2018Article
- Proteolytic activity assayed by subcellular localization switching of a substrate.Biochemistry and biophysics reports · 2016Article
- A HIV-1 Tat mutant protein disrupts HIV-1 Rev function by targeting the DEAD-box RNA helicase DDX1.Retrovirology · 2014Article
- A nuclear export signal within the structural Gag protein is required for prototype foamy virus replication.Retrovirology · 2011Article
- Article
- HIV-1 Rev oligomerization is not obligatory in the presence of an extra basic domain.Retrovirology · 2005Article
- A nuclear kinesin-like protein interacts with and stimulates the activity of the leucine-rich nuclear export signal of the human immunodeficiency virus type 1 rev protein.Journal of virology · 2003Article
- Rev inhibition strongly affects intracellular distribution of human immunodeficiency virus type 1 RNAs.Journal of virology · 2002Article
- Identification of a domain in human immunodeficiency virus type 1 rev that is required for functional activity and modulates association with subnuclear compartments containing splicing factor SC35.Journal of virology · 2000Article
- HIV-1 rev depolymerizes microtubules to form stable bilayered rings.The Journal of cell biology · 2000Article
- Titration of cellular export factors, but not heteromultimerization, is the molecular mechanism of trans-dominant HTLV-1 rex mutants.Oncogene · 1999Article
- ICP27 mediates HSV RNA export by shuttling through a leucine-rich nuclear export signal and binding viral intronless RNAs through an RGG motif.Genes & development · 1998Article
- Nuclear import and export of influenza virus nucleoprotein.Journal of virology · 1997Article
- Inhibition of human T-cell leukemia virus type 2 Rex function by truncated forms of Rex encoded in alternatively spliced mRNAs.Journal of virology · 1997Article
- A structured retroviral RNA element that mediates nucleocytoplasmic export of intron-containing RNA.Molecular and cellular biology · 1997Article
- Human immunodeficiency virus type 1 Rev function requires continued synthesis of its target mRNA.Journal of virology · 1996Article
- Redistribution of the delta antigens in cells replicating the genome of hepatitis delta virus.Journal of virology · 1996Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human immunodeficiency virus type 1 nucleocytoplasmic shuttle protein Rev moves repeatedly between the cytoplasm, a perinuclear zone, the nucleoli, and nucleoplasmic speckles. In this study, we demonstrated by both indirect immunofluorescence and Western immunoblot analysis that nuclear exit of Rev transdominant negative mutants was defective compared with that of wild-type Rev. The basic and activation domains of Rev signal import and export, respectively, of Rev across the nuclear membrane. In cotransfection experiments, mutants containing mutations of Rev inhibited the nuclear egress of wild-type Rev, thus revealing a novel transdominant negative phenotype.
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