ArticleThe Journal of cell biology1995
Distribution of alpha-dystroglycan during embryonic nerve-muscle synaptogenesis.
Article in The Journal of cell biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 68 citations in OpenAlex.
- Postsynaptic receptors regulate presynaptic transmitter stability through transsynaptic bridges.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- In Vitro Innervation as an Experimental Model to Study the Expression and Functions of Acetylcholinesterase and Agrin in Human Skeletal Muscle.Molecules (Basel, Switzerland) · 2017Review
- Article
- Laminins promote postsynaptic maturation by an autocrine mechanism at the neuromuscular junction.The Journal of cell biology · 2008Article
- Cloning and expression patterns of dystroglycan during the early development of Xenopus laevis.Development genes and evolution · 2003Article
- Mechanistic distinctions between agrin and laminin-1 induced aggregation of acetylcholine receptors.BMC neuroscience · 2002Article
- Src-class kinases act within the agrin/MuSK pathway to regulate acetylcholine receptor phosphorylation, cytoskeletal anchoring, and clustering.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- The dystroglycan complex is necessary for stabilization of acetylcholine receptor clusters at neuromuscular junctions and formation of the synaptic basement membrane.The Journal of cell biology · 2001Article
- alpha-Dystroglycan is a laminin receptor involved in extracellular matrix assembly on myotubes and muscle cell viability.The Journal of cell biology · 1999Article
- Acetylcholinesterase clustering at the neuromuscular junction involves perlecan and dystroglycan.The Journal of cell biology · 1999Article
- Neurotrophins regulate agrin-induced postsynaptic differentiation.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- alpha-Dystroglycan functions in acetylcholine receptor aggregation but is not a coreceptor for agrin-MuSK signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Laminin and alpha-dystroglycan mediate acetylcholine receptor aggregation via a MuSK-independent pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Laminin-induced acetylcholine receptor clustering: an alternative pathway.The Journal of cell biology · 1997Article
- Intercellular communication that mediates formation of the neuromuscular junction.Molecular neurobiology · 1997Review
- Common molecular mechanisms in field- and agrin-induced acetylcholine receptor clustering.Cellular and molecular neurobiology · 1997Article
- Laminin-induced clustering of dystroglycan on embryonic muscle cells: comparison with agrin-induced clustering.The Journal of cell biology · 1997Article
- Increased expression of dystrophin, beta-dystroglycan and adhalin in denervated rat muscles.Journal of muscle research and cell motility · 1996Article
- AChR phosphorylation and aggregation induced by an agrin fragment that lacks the binding domain for alpha-dystroglycan.The EMBO journal · 1996Article
- An amino-terminal extension is required for the secretion of chick agrin and its binding to extracellular matrix.The Journal of cell biology · 1995Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The distribution of alpha-dystroglycan (alpha DG) relative to acetylcholine receptors (AChRs) and neural agrin was examined by immunofluorescent staining with mAb IIH6 in cultures of nerve and muscle cells derived from Xenopus embryos. In Western blots probed with mAb IIH6, alpha DG was evident in membrane extracts of Xenopus muscle but not brain. alpha DG immunofluorescence was present at virtually all synaptic clusters of AChRs and neural agrin. Even microclusters of AChRs and agrin at synapses no older than 1-2 h (the earliest examined) had alpha DG associated with them. alpha DG was also colocalized at the submicrometer level with AChRs at nonsynaptic clusters that have little or no agrin. The number of large (> 4 microns) nonsynaptic clusters of alpha DG, like the number of large nonsynaptic clusters of AChRs, was much lower on innervated than on noninnervated cells. When mAb IIH6 was included in the culture medium, the large nonsynaptic clusters appeared fragmented and less compact, but the accumulation of agrin and AChRs along nerve-muscle contacts was not prevented. It is concluded that during nerve-muscle synaptogenesis, alpha DG undergoes the same nerve-induced changes in distribution as AChRs. We propose a diffusion trap model in which the alpha DG-transmembrane complex participates in the anchoring and recruitment of AChRs and alpha DG during the formation of synaptic as well as nonsynaptic AChR clusters.
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