ArticleThe Journal of cell biology1995
Spnr, a murine RNA-binding protein that is localized to cytoplasmic microtubules.
Article in The Journal of cell biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 105 citations in OpenAlex.
- Article
- The RNA-binding protein Adad1 is necessary for germ cell maintenance and meiosis in zebrafish.PLoS genetics · 2023Article
- The Emerging Role of ncRNAs and RNA-Binding Proteins in Mitotic Apparatus Formation.Non-coding RNA · 2020Review
- Nuclear factor 90 uses an ADAR2-like binding mode to recognize specific bases in dsRNA.Nucleic acids research · 2016Article
- Proteomic Profiling of Neuroblastoma Cells Adhesion on Hyaluronic Acid-Based Surface for Neural Tissue Engineering.BioMed research international · 2016Article
- Interaction between microRNAs and actin-associated protein Arpc5 regulates translational suppression during male germ cell differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Expression of STRBP mRNA in patients with cryptorchidism and Down's syndrome.Journal of endocrinological investigation · 2012Article
- Zygotic expression of the double-stranded RNA binding motif protein Drb2p is required for DNA elimination in the ciliate Tetrahymena thermophila.Eukaryotic cell · 2011Article
- siRNA repositioning for guide strand selection by human Dicer complexes.Molecular cell · 2011Article
- Analysis of microRNA expression in the prepubertal testis.PloS one · 2010Article
- Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense.Genes & development · 2010Article
- Molecular biological features of male germ cell differentiation.Reproductive medicine and biology · 2007Review
- Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins.The Journal of cell biology · 2002Article
- The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells.Molecular and cellular biology · 2002Article
- RNA-dependent cytoplasmic anchoring of a transcription factor subunit during Xenopus development.The EMBO journal · 2000Article
- A new double-stranded RNA-binding protein that interacts with PKR.Nucleic acids research · 2000Article
- Isolation of a trans-acting factor involved in localization of Paracentrotus lividus maternal mRNAs.RNA (New York, N.Y.) · 1999Article
- Two distinct forms of the 64,000 Mr protein of the cleavage stimulation factor are expressed in mouse male germ cells.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Sequence-independent assembly of spermatid mRNAs into messenger ribonucleoprotein particles.Molecular and cellular biology · 1999Article
- Mammalian staufen is a double-stranded-RNA- and tubulin-binding protein which localizes to the rough endoplasmic reticulum.Molecular and cellular biology · 1999Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies in transgenic mice have established the importance of the 3' untranslated region (UTR) of the spermatid-specific protamine-1 (Prm-1) mRNA in its translational control during male germ cell development. To clone genes that mediate the translational repression or activation of the Prm-1 mRNA, we screened cDNA expression libraries made with RNA from pachytene spermatocytes and round spermatids, with an RNA probe corresponding to the 3' UTR of Prm-1. We obtained six independent clones that encode Spnr, a spermatid perinuclear RNA-binding protein. Spnr is a 71-kD protein that contains two previously described RNA binding domains. The Spnr mRNA is expressed at high levels in the testis, ovary, and brain, and is present in multiple forms in those tissues. Immunolocalization of the Spnr protein within the testis shows that it is expressed exclusively in postmeiotic germ cells and that it is localized to the manchette, a spermatid-specific microtubular array. Although the Spnr protein is expressed too late to be directly involved in the translational repression of Prm-1 specifically, we suggest that the Spnr protein may be involved in other aspects of spermatid RNA metabolism, such as RNA transport or translational activation.
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