ArticleClinical and experimental immunology1995
Macrophages in T cell line-mediated, demyelinating, and chronic relapsing experimental autoimmune encephalomyelitis in Lewis rats.
Article in Clinical and experimental immunology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 111 citations in OpenAlex.
- Pilot trial of intravenous infusion of a replication-selective adenovirus (ONYX-015) in combination with chemotherapy or IL-2 treatment in refractory cancer patients.Cancer gene therapy · 2003Trial
- Intravenous infusion of a replication-selective adenovirus (ONYX-015) in cancer patients: safety, feasibility and biological activity.Gene therapy · 2001Trial
- Characteristic patterns of complement deposition in NMOSD, MOGAD, and MS.Acta neuropathologica · 2026Article
- A Western diet impairs CNS energy homeostasis and recovery after spinal cord injury: Link to astrocyte metabolism.Neurobiology of disease · 2020Article
- Low-Density Lipoprotein Receptor Deficiency Attenuates Neuroinflammation through the Induction of Apolipoprotein E.Frontiers in immunology · 2017Article
- Lessons Learned about Neurodegeneration from Microglia and Monocyte Depletion Studies.Frontiers in aging neuroscience · 2017Review
- Hydroxycitric acid ameliorates inflammation and oxidative stress in mouse models of multiple sclerosis.Neural regeneration research · 2016Article
- Multiple sclerosis: myeloperoxidase immunoradiology improves detection of acute and chronic disease in experimental model.Radiology · 2015Article
- Enhanced uptake of multiple sclerosis-derived myelin by THP-1 macrophages and primary human microglia.Journal of neuroinflammation · 2014Article
- Treatment for experimental autoimmune neuritis with clodronate (Bonefos).Immunologic research · 2013Article
- Article
- Tyrosine kinase inhibitors ameliorate autoimmune encephalomyelitis in a mouse model of multiple sclerosis.Journal of clinical immunology · 2011Article
- Myelin-phagocytosing macrophages modulate autoreactive T cell proliferation.Journal of neuroinflammation · 2011Article
- CCR4 contributes to the pathogenesis of experimental autoimmune encephalomyelitis by regulating inflammatory macrophage function.Journal of neuroimmunology · 2011Article
- Glatiramer acetate treatment increases stability of spinal synapses and down regulates MHC I during the course of EAE.International journal of biological sciences · 2011Article
- Central neuroinvasion and demyelination by inflammatory macrophages after peripheral virus infection is controlled by SHP-1.Viral immunology · 2009Article
- The role of macrophages in optic nerve regeneration.Neuroscience · 2009Review
- Modulation of macrophage infiltration and inflammatory activity by the phosphatase SHP-1 in virus-induced demyelinating disease.Journal of virology · 2009Article
- Roles of PI3K and JAK pathways in viability of retinal ganglion cells after acute elevation of intraocular pressure in rats with different autoimmune backgrounds.BMC neuroscience · 2008Article
- [Update on pathophysiologic and immunotherapeutic approaches for the treatment of multiple sclerosis].Der Nervenarzt · 2007Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
About 50% of the mononuclear cells in the perivascular lesions in the central nervous system (CNS) of rats suffering from experimental allergic encephalomyelitis (EAE) are blood-borne macrophages. In this study we investigated the role of these macrophages in different variants of EAE, using a liposome-mediated macrophage depletion technique. Intravenously injected liposomes containing dichloromethylene diphosphonate (Cl2MDP) are ingested by macrophages and cause temporary and selective elimination of these cells. Macrophage depletion during EAE induced by a T cell line specific for myelin basic protein (MBP; T cell-EAE) suppresses development of neurological signs of EAE. T cell-EAE with pronounced demyelination as induced by an additionally injected MoAb directed against myelin oligodendrocyte glycoprotein (MOG) was also significantly ameliorated after macrophage depletion. During chronic relapsing EAE (CR-EAE) the occurrence of relapses was prevented or suppressed, provided that the liposomes were injected before the initiation of a putative relapse. A chronic progressive course of CR-EAE was not modified by Cl2MDP containing liposome treatment. Histologic examination of the CNS of liposome-treated animals confirmed decreased infiltration of macrophages into the parenchyma in the rats with T cell and AD-EAE, whereas T cells were still present.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.