ReviewSports medicine (Auckland, N.Z.)1995
Exercise, training and red blood cell turnover.
Review in Sports medicine (Auckland, N.Z.), 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it, 199 citations in OpenAlex.
- Pooled it
- Impact of intensified training and carbohydrate supplementation on immunity and markers of overreaching in highly trained cyclists.European journal of applied physiology · 2016Trial
- Oxidative Stress Assessment in Response to Ultraendurance Exercise: Thiols Redox Status and ROS Production according to Duration of a Competitive Race.Oxidative medicine and cellular longevity · 2016Trial
- Hemorheological responses to progressive resistance exercise training in healthy young males.Medical science monitor : international medical journal of experimental and clinical research · 2012Trial
- Changes in haematological parameters and iron metabolism associated with a 1600 kilometre ultramarathon.British journal of sports medicine · 1999Trial
- Changes in the susceptibility of red blood cells to oxidative and osmotic stress following submaximal exercise.European journal of applied physiology and occupational physiology · 1995Trial
- Long-Distance Trail Running Induces Inflammatory-Associated Protein, Lipid, and Purine Oxidation in Red Blood Cells.Blood red cells & iron · 2026Article
- Running on the edge: hematological responses to a non-stop ultramarathon with a focus on nitric oxide-mediated red blood cell deformability.Frontiers in physiology · 2025Article
- Red Blood Cell Distribution Width, Erythrocyte Indices, and Elongation Index at Baseline in a Group of Trained Subjects.Journal of clinical medicine · 2023Article
- Influence of iron supplementation on fatigue, mood states and sweating profiles of healthy non-anemic athletes during a training exercise: A double-blind, randomized, placebo-controlled, parallel-group study.Contemporary clinical trials communications · 2023Article
- Effects of Rowing on Rheological Properties of Blood.International journal of environmental research and public health · 2023Article
- Concerted phenotypic flexibility of avian erythrocyte size and number in response to dietary anthocyanin supplementation.Frontiers in zoology · 2023Article
- Empowering frail older adults: multicomponent elastic-band exercises and BCAA supplementation unleash physical health and preserve haematological biomarkers.Frontiers in sports and active living · 2023Article
- L-Glutamine is better for treatment than prevention in exhaustive exercise.Frontiers in physiology · 2023Article
- Autologous Blood Doping Induced Changes in Red Blood Cell Rheologic Parameters, RBC Age Distribution, and Performance.Biology · 2022Article
- Changes in blood rheological properties and biochemical markers after participation in the XTERRA Poland triathlon competition.Scientific reports · 2022Article
- Benefits on Hematological and Biochemical Parameters of a High-Intensity Interval Training Program for a Half-Marathon in Recreational Middle-Aged Women Runners.International journal of environmental research and public health · 2022Article
- MiRNA-based "fitness score" to assess the individual response to diet, metabolism, and exercise.Journal of the International Society of Sports Nutrition · 2022Article
- Recommendations and Nutritional Considerations for Female Athletes: Health and Performance.Sports medicine (Auckland, N.Z.) · 2021Review
- Skeletal muscle heme oxygenase-1 activity regulates aerobic capacity.Cell reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endurance training can lead to what has been termed 'sports anaemia'. Although under normal conditions, red blood cells (RBCs) have a lifespan of about 120 days, the rate of aging may increase during intensive training. However, RBC deficiency is rare in athletes, and sports anaemia is probably due to an expanded plasma volume. Cycling, running and swimming have been shown to cause RBC damage. While most investigators measure indices of haemolysis (for example, plasma haemoglobin or haptoglobin), RBC removal is normally an extravascular process that does not involve haemolysis. Attention is now turning to cellular indices (such as antioxidant depletion, or protein or lipid damage) that may be more indicative of exercise-induced damage. RBCs are vulnerable to oxidative damage because of their continuous exposure to oxygen and their high concentrations of polyunsaturated fatty acids and haem iron. As oxidative stress may be proportional to oxygen uptake, it is not surprising that antioxidants in muscle, liver and RBCs can be depleted during exercise. Oxidative damage to RBCs can also perturb ionic homeostasis and facilitate cellular dehydration. These changes impair RBC deformability which can, in turn, impede the passage of RBCs through the microcirculation. This may lead to hypoxia in working muscle during single episodes of exercise and possibly an increased rate of RBC destruction with long term exercise. Providing RBC destruction does not exceed the rate of RBC production, no detrimental effect to athletic performance should occur. An increased rate of RBC turnover may be advantageous because young cells are more efficient in transporting oxygen. Because most techniques examine the RBC population as a whole, more sophisticated methods which analyse cells individually are required to determine the mechanisms involved in exercise-induced damage of RBCs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.