ArticleNucleic acids research1995
Analysis of hepatocyte nuclear factor-3 beta protein domains required for transcriptional activation and nuclear targeting.
Article in Nucleic acids research, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- FOXA2 in islet biology: Orchestrating pancreatic development and glucose homeostasis.Genes & diseases · 2026Review
- Alterations in AR-FOXA1 signaling in prostate cancer progression and therapeutic resistance.Journal of the National Cancer Center · 2026Review
- Mutations of CYP1B1 and FOXC1 genes for childhood glaucoma in Japanese individuals.Japanese journal of ophthalmology · 2024Article
- Transcription networks in liver development and acute liver failure.Liver research (Beijing, China) · 2023Review
- Whole-exome sequencing identifies FOXL2, FOXA2 and FOXA3 as candidate genes for monogenic congenital anomalies of the kidneys and urinary tract.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022Article
- Transcription Control of Liver Development.Cells · 2021Review
- Gene network transitions in embryos depend upon interactions between a pioneer transcription factor and core histones.Nature genetics · 2020Article
- SUMOylation and phosphorylation cross-talk in hepatocellular carcinoma.Translational gastroenterology and hepatology · 2018Review
- Identification of an alveolar type I epithelial cell-specific DNA nuclear import sequence for gene delivery.Gene therapy · 2016Article
- Arx together with FoxA2, regulates Shh floor plate expression.Developmental biology · 2014Article
- R164C mutation in FOXQ1 H3 domain affects formation of the hair medulla.Experimental dermatology · 2013Article
- FOXA1: a transcription factor with parallel functions in development and cancer.Bioscience reports · 2012Review
- A regulatory domain is required for Foxn4 activity during retinogenesis.Journal of molecular neuroscience : MN · 2012Article
- Forkhead box protein A2 (FOXA2) protein stability and activity are regulated by sumoylation.PloS one · 2012Article
- Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2.PLoS genetics · 2012Article
- FOXA2 functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers.Cell research · 2011Article
- Zebrafish cyclin-dependent protein kinase-like 1 (zcdkl1): identification and functional characterization.International journal of molecular sciences · 2011Article
- Structural and functional characterisation of the fork head transcription factor-encoding gene, Hc-daf-16, from the parasitic nematode Haemonchus contortus (Strongylida).International journal for parasitology · 2010Article
- Structure and functions of powerful transactivators: VP16, MyoD and FoxA.The International journal of developmental biology · 2010Review
- ErbB3 binding protein 1 represses metastasis-promoting gene anterior gradient protein 2 in prostate cancer.Cancer research · 2010Article
Corrections and comments
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2 authors.
Funding
Abstract
Three distinct hepatocyte nuclear factor 3 (HNF-3) proteins (alpha, beta and gamma) regulate transcription of the transthyretin (TTR) and numerous other liver-specific genes. The HNF-3 proteins bind DNA via a homologous winged helix motif common to a number of developmental regulatory proteins including the Drosophila homeotic fork head (fkh) protein. The mammalian HNF-3/fkh family consists of at least thirty distinct members and is expressed in a variety of different cellular lineages. In addition to the winged helix motif, several HNF-3/fkh family members also share homology within transcriptional activation region II and III sequences. In the present study we further define the sequence boundaries of the HNF-3 beta N-terminal transcriptional activation domain to extend from amino acids 14 to 93 and include conserved region IV and V sequences. We also demonstrate that activity of the HNF-3 N-terminal domain was diminished by mutations which altered a putative alpha-helical structure located between amino acid residues 14 and 19. However, transcriptional activity was not affected by mutations which eliminated two conserved casein kinase I sites or increased the number of acidic amino acid residues in the N-terminal domain. Furthermore, we determined that the nuclear localization signal overlaps with the winged helix DNA-binding motif. These results suggest that conserved sequences within the winged helix motif of the HNF-3/fkh family may be involved not only in DNA recognition, but also in nuclear targeting.
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