ArticleMolecular and cellular biology1995
Upstream stimulatory factor regulates expression of the cell cycle-dependent cyclin B1 gene promoter.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 122 citations in OpenAlex.
- USF2 and TFEB compete in regulating lysosomal and autophagy genes.Nature communications · 2024Article
- Targeting radiation-induced upstream stimulatory factor-1 by histone deacetylase inhibitors to reverse radioresistance in prostate cancer.Cancer reports (Hoboken, N.J.) · 2022Article
- Impact of Global Transcriptional Silencing on Cell Cycle Regulation and Chromosome Segregation in Early Mammalian Embryos.International journal of molecular sciences · 2021Review
- Selective repression of the Drosophila cyclin B promoter by retinoblastoma and E2F proteins.Biochimica et biophysica acta. Gene regulatory mechanisms · 2020Article
- The positive circadian regulators CLOCK and BMAL1 control G2/M cell cycle transition through Cyclin B1.Cell cycle (Georgetown, Tex.) · 2019Article
- Identification of novel cyclin gene fusion transcripts in endometrioid ovarian carcinomas.International journal of cancer · 2018Article
- Minute Virus of Mice Inhibits Transcription of the Cyclin B1 Gene during Infection.Journal of virology · 2017Article
- Derivation of a novel G2 reporter system.Cytotechnology · 2016Article
- Article
- Profiling of the BRCA1 transcriptome through microarray and ChIP-chip analysis.Nucleic acids research · 2011Article
- Mitotic progression becomes irreversible in prometaphase and collapses when Wee1 and Cdc25 are inhibited.Molecular biology of the cell · 2011Article
- Mutated beta-catenin evades a microRNA-dependent regulatory loop.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Target gene specificity of USF-1 is directed via p38-mediated phosphorylation-dependent acetylation.The Journal of biological chemistry · 2009Article
- HINT1 inhibits beta-catenin/TCF4, USF2 and NFkappaB activity in human hepatoma cells.International journal of cancer · 2009Article
- Cdk5-mediated phosphorylation of c-Myc on Ser-62 is essential in transcriptional activation of cyclin B1 by cyclin G1.The Journal of biological chemistry · 2008Article
- Cyclin G1 overcomes radiation-induced G2 arrest and increases cell death through transcriptional activation of cyclin B1.Cell death and differentiation · 2006Article
- O2 enhancement of human trophoblast differentiation and hCYP19 (aromatase) gene expression are mediated by proteasomal degradation of USF1 and USF2.Molecular and cellular biology · 2005Article
- Upstream stimulatory factors, USF1 and USF2, bind to the human haem oxygenase-1 proximal promoter in vivo and regulate its transcription.The Biochemical journal · 2004Article
- The p75NTR-interacting protein SC1 inhibits cell cycle progression by transcriptional repression of cyclin E.The Journal of cell biology · 2004Article
- Control of cyclin G2 mRNA expression by forkhead transcription factors: novel mechanism for cell cycle control by phosphoinositide 3-kinase and forkhead.Molecular and cellular biology · 2004Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Progression through the somatic cell cycle requires the temporal regulation of cyclin gene expression and cyclin protein turnover. One of the best-characterized examples of this regulation is seen for the B-type cyclins. These cyclins and their catalytic component, cdc2, have been shown to mediate both the entry into and maintenance of mitosis. The cyclin B1 gene has been shown to be expressed between the late S and G2 phases of the cell cycle, while the protein is degraded specifically at interphase via ubiquitination. To understand the molecular basis for transcriptional regulation of the cyclin B1 gene, we cloned the human cyclin B1 gene promoter region. Using a chloramphenicol acetyltransferase reporter system and both stable and transient assays, we have shown that the cyclin B1 gene promoter (extending to -3800 bp relative to the cap site) can confer G2-enhanced promoter activity. Further analysis revealed that an upstream stimulatory factor (USF)-binding site and its cognate transcription factor(s) are critical for expression from the cyclin B1 promoter in cycling HeLa cells. Interestingly, USF DNA-binding activity appears to be regulated in a G2-specific fashion, supporting the idea that USF may play some role in cyclin B1 gene activation. These studies suggest an important link between USF and the cyclin B1 gene, which in part explains how maturation promoting factor complex formation is regulated.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.