ArticleThe Journal of clinical investigation1995
Glucose modulates rat substantia nigra GABA release in vivo via ATP-sensitive potassium channels.
Article in The Journal of clinical investigation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 95 citations in OpenAlex.
- Association of diabetes with dyskinesia in older psychosis patients.Psychopharmacology · 2004Trial
- The effect of modafinil on counter-regulatory and cognitive responses to hypoglycaemia.Diabetologia · 2004Trial
- Role of dopamine in the development of impaired counterregulation and impaired awareness of hypoglycemia.Cell reports. Medicine · 2026Article
- Emerging Perspectives on the Impact of Diabetes Mellitus and Anti-Diabetic Drugs on Premenstrual Syndrome. A Narrative Review.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2024Review
- Do KFrontiers in immunology · 2024Review
- Fasting may increase incentive signaling for nonfood rewards.Nutrition research (New York, N.Y.) · 2020Article
- Glucose modulates food-related salience coding of midbrain neurons in humans.Human brain mapping · 2016Article
- Inhibitory and excitatory neuromodulation by hydrogen peroxide: translating energetics to information.The Journal of physiology · 2015Review
- Differential effects of fructose versus glucose on brain and appetitive responses to food cues and decisions for food rewards.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Complex Membrane Channel Blockade: A Unifying Hypothesis for the Prodromal and Acute Neuropsychiatric Sequelae Resulting from Exposure to the Antimalarial Drug Mefloquine.Journal of parasitology research · 2015Review
- GLUT2-mediated glucose uptake and availability are required for embryonic brain development in zebrafish.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Article
- Striatal dopamine homeostasis is altered in mice following Roux-en-Y gastric bypass surgery.ACS chemical neuroscience · 2014Article
- Glucose utilization rates regulate intake levels of artificial sweeteners.The Journal of physiology · 2013Article
- Circulating glucose levels modulate neural control of desire for high-calorie foods in humans.The Journal of clinical investigation · 2011Article
- Increased GABAergic output in the ventromedial hypothalamus contributes to impaired hypoglycemic counterregulation in diabetic rats.Diabetes · 2011Article
- Nutrient selection in the absence of taste receptor signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Septal co-infusions of glucose with the benzodiazepine agonist chlordiazepoxide impair memory, but co-infusions of glucose with the opiate morphine do not.Physiology & behavior · 2010Article
- Zero net flux estimates of septal extracellular glucose levels and the effects of glucose on septal extracellular GABA levels.European journal of pharmacology · 2009Article
- Metabolic environment in substantia nigra reticulata is critical for the expression and control of hypoglycemia-induced seizures.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Glucose modulates beta cell insulin secretion via effects on ATP-sensitive potassium (KATP) channels. To test the hypothesis that glucose exerts a similar effect on neuronal function, local glucose availability was varied in awake rats using microdialysis in the substantia nigra, the brain region with the highest density of KATP channels. 10 mM glucose perfusion increased GABA release by 111 +/- 42%, whereas the sulfonylurea, glipizide, increased GABA release by 84 +/- 20%. In contrast, perfusion of the KATP channel activator, lemakalim, or depletion of ATP by perfusion of 2-deoxyglucose with oligomycin inhibited GABA release by 44 +/- 8 and 45 +/- 11%, respectively. Moreover, the inhibition of GABA release by 2-deoxyglucose and oligomycin was blocked by glipizide. During systemic insulin-induced hypoglycemia (1.8 +/- 0.3 mM), nigral dialysate GABA concentrations decreased by 49 +/- 4% whereas levels of dopamine in striatal dialysates increased by 119 +/- 18%. We conclude that both local and systemic glucose availability influences nigral GABA release via an effect on KATP channels and that inhibition of GABA release may in part mediate the hyperexcitability associated with hypoglycemia. These data support the hypothesis that glucose acts as a signaling molecule, and not simply as an energy-yielding fuel, for neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.