ArticleThe Journal of clinical investigation1995
Modulation of skeletal muscle sodium channels by human myotonin protein kinase.
Article in The Journal of clinical investigation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 54 citations in OpenAlex.
- Assessing the Safety and Efficacy of Lamotrigine as Anti-myotonic Agent in Myotonic Dystrophy Type 1 (DM1): A Longitudinal, Open-Label, Pilot Study.Neurology and therapy · 2025Article
- In vivo assessment of muscle membrane properties in myotonic dystrophy.Muscle & nerve · 2016Article
- Sodium Channel Inhibitors Reduce DMPK mRNA and Protein.Clinical and translational science · 2015Article
- The STE20/germinal center kinase POD6 interacts with the NDR kinase COT1 and is involved in polar tip extension in Neurospora crassa.Molecular biology of the cell · 2006Article
- Alternative splicing controls myotonic dystrophy protein kinase structure, enzymatic activity, and subcellular localization.Molecular and cellular biology · 2003Article
- Sodium channel isoform-specific effects of halothane: protein kinase C co-expression and slow inactivation gating.British journal of pharmacology · 2000Article
- Protein kinase C co-expression and the effects of halothane on rat skeletal muscle sodium channels.British journal of pharmacology · 1999Article
- Structure and function of voltage-gated sodium channels.The Journal of physiology · 1998Review
- Vibrational spectra of individual millimeter-size membrane patches using miniature infrared waveguides.Biophysical journal · 1997Article
- Myotonic dystrophy protein kinase is involved in the modulation of the Ca2+ homeostasis in skeletal muscle cells.The Journal of clinical investigation · 1997Article
- Evidence for localization of the myotonic dystrophy protein kinase to the terminal cisternae of the sarcoplasmic reticulum.Journal of muscle research and cell motility · 1997Article
- The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton.Molecular and cellular biology · 1996Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
In myotonic muscular dystrophy, abnormal muscle Na currents underlie myotonic discharges. Since the myotonic muscular dystrophy gene encodes a product, human myotonin protein kinase, with structural similarity to protein kinases, we tested the idea that human myotonin protein kinase modulates skeletal muscle Na channels. Coexpression of human myotonin protein kinase with rat skeletal muscle Na channels in Xenopus oocytes reduced the amplitude of Na currents and accelerated current decay. The effect required the presence of a potential phosphorylation site in the inactivation mechanism of the channel. The mutation responsible for human disease, trinucleotide repeats in the 3' untranslated region, did not prevent the effect. The consequence of an abnormal amount of the kinase would be altered muscle cell excitability, consistent with the clinical finding of myotonia in myotonic dystrophy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.