ArticleThe EMBO journal1995
Contrasting effects of alpha and beta globin regulatory elements on chromatin structure may be related to their different chromosomal environments.
Article in The EMBO journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 93 citations in OpenAlex.
- Lentiviral vectors for hematopoietic stem cell gene therapy restore α-globin expression in α-thalassemia red blood cells.Cell reports. Medicine · 2025Article
- Review
- Co-Regulated Genes and Gene Clusters.Genes · 2021Review
- Activation of the alpha-globin gene expression correlates with dramatic upregulation of nearby non-globin genes and changes in local and large-scale chromatin spatial structure.Epigenetics & chromatin · 2017Article
- 3D genomics imposes evolution of the domain model of eukaryotic genome organization.Chromosoma · 2017Review
- Characterization of the enhancer element of the Danio rerio minor globin gene locus.Histochemistry and cell biology · 2016Article
- Uncovering enhancer functions using the α-globin locus.PLoS genetics · 2014Review
- Distinct distribution of ectopically expressed histone variants H2A.Bbd and MacroH2A in open and closed chromatin domains.PloS one · 2012Article
- Dynamic plasticity of large-scale chromatin structure revealed by self-assembly of engineered chromosome regions.The Journal of cell biology · 2010Article
- TMEM8 - a non-globin gene entrapped in the globin web.Nucleic acids research · 2009Article
- Long-range chromosomal interactions regulate the timing of the transition between poised and active gene expression.The EMBO journal · 2007Article
- A CTCF-dependent silencer located in the differentially methylated area may regulate expression of a housekeeping gene overlapping a tissue-specific gene domain.Molecular and cellular biology · 2006Article
- Review
- Differences of globin transgene expression in stably transfected cell lines and transgenic mice.Blood · 2005Article
- The control of expression of the alpha-globin gene cluster.International journal of hematology · 2002Review
- The expression of human alpha -like globin genes in transgenic mice mediated by bacterial artificial chromosome.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Identification of a conserved erythroid specific domain of histone acetylation across the alpha-globin gene cluster.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Chromatin interaction mechanism of transcriptional control in vivo.The EMBO journal · 1998Article
- The locus control region is necessary for gene expression in the human beta-globin locus but not the maintenance of an open chromatin structure in erythroid cells.Molecular and cellular biology · 1998Article
- Comparison of the human and murine ATRX gene identifies highly conserved, functionally important domains.Mammalian genome : official journal of the International Mammalian Genome Society · 1998Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Expression of the human alpha and beta globin gene clusters is regulated by remote sequences, referred to as HS -40 and the beta-locus control region (beta-LCR) that lie 5-40 kb upstream of the genes they activate. Because of their common ancestry, similar organization and coordinate expression it has often been assumed that regulation of the globin gene clusters by HS -40 and the beta-LCR occurs via similar mechanisms. Using interspecific hybrids containing chromosomes with naturally occurring deletions of HS -40 we have shown that, in contrast to the beta-LCR, this element exerts no discernible effect on long-range chromatin structure and in addition does not influence formation of DNase I hypersensitive sites at the alpha globin promoters. These differences in the behaviour of HS -40 and the beta-LCR may reflect their contrasting influence on gene expression in transgenic mice and may result from the differing requirements of these elements in their radically different, natural chromosomal environments; the alpha cluster lying within a region of constitutively 'open' chromatin and the beta cluster in a segment of chromatin which opens in a tissue-specific manner. Differences in the hierarchical control of the alpha and beta globin clusters may exemplify more general differences in the regulation of eukaryotic genes which lie in similar open or closed chromosomal regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.