Evidence map›Paper›PMID 7734973›Full record

ReviewEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery1995

Nonallergic rhinitis. Pathophysiology and models for study.

G Philip, A G Togias

Abstract readReview
PubMed Publisher
In one paragraph

Review in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Nonallergic rhinitis.Current allergy and asthma reports · 2014
    Review
  3. Tonic stimulation of the pharyngeal mucosa causes pain and a reversible increase of inflammatory mediators.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2013
    Article
  4. Environmental and non-infectious factors in the aetiology of pharyngitis (sore throat).Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012
    Review
  5. Article
  6. Vasomotor rhinitis.Current allergy and asthma reports · 2010
    Review
  7. Capsaicin treatment of idiopathic rhinitis: the new panacea?Current allergy and asthma reports · 2006
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

G PhilipDepartment of Medicine, Johns Hopkins Asthma & Allergy Center, Baltimore, MD 21224-6801, USA.
A G Togias

Funding

BASIC AND CLINICAL IMMUNOLOGYT32AI007056 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BOCHNER, BRUCE S · 1985 to 2012
$2.9M
MECHANISMS OF HUMAN AIRWAY REACTIONS TO DRY AIRR29HL048248 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TOGIAS, ALKIS G. · 1993 to 1997
–
NHLBI NIH HHS R29 HL-48248NIAID NIH HHS AI-07056
6 · The paper itself

Abstract

Nonallergic rhinitis is a diagnosis of exclusion which is given to patients who suffer perennial nasal congestion, rhinorrhea, and/or sneezing with no identifiable allergic etiology. Because there is still no clear understanding of the pathophysiology, it is possible that a number of different disease processes may be included within this clinically defined entity. This report does not attempt to present an overall discussion of the clinical approaches to patients with nonallergic rhinitis. Instead, an outline is presented of various research approaches which may be used in its study. A number of nasal provocation models using nonallergic stimuli are available for application in the laboratory. These include intranasal methacholine challenges, intranasal histamine challenges, nasal inhalation of cold dry air, and intranasal capsaicin challenges. These models provide certain insights into mechanisms of nonallergic hyper-responsiveness. An additional approach to the study of nonallergic rhinitis is to examine available therapies, allowing the clinician to evaluate various pathways of importance in the disease process. These approaches provide a certain understanding of this common but perplexing entity, although further study is still required.

Indexed as

CapsaicinCold TemperatureHistamineHumansMethacholine ChlorideNasal MucosaNasal Provocation TestsRhinitisCapsaicinHistamineMethacholine Chloride

Identifiers

PMID7734973

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.