ArticleInternational journal of experimental pathology1994
Human mast cells produce type VIII collagen in vivo.
Article in International journal of experimental pathology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Type VIII collagen: advances in matrix biology and translational promise.Frontiers in bioengineering and biotechnology · 2025Pooled it
- Association Between Allergy, Asthma, and Cancer: The Japan Public Health Center-Based Prospective Study.Cancer medicine · 2026Article
- Immune cell fibrotic plasticity: mesenchymal-like reprogramming of macrophages, neutrophils and T cells.Frontiers in immunology · 2026Review
- Collagen VIII in vascular diseases.Matrix biology : journal of the International Society for Matrix Biology · 2024Review
- Burn Wound Healing Activity of Hydroxyethylcellulose Gels with Different Water Extracts Obtained from Various Medicinal Plants inInternational journal of molecular sciences · 2024Article
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- The associations between mast cell infiltration, clinical features and molecular types of invasive breast cancer.Oncotarget · 2016Article
- The role of mast cells in cancers.F1000prime reports · 2015Review
- Expression of genes encoding extracellular matrix proteins: a macroarray study.Oncology reports · 2014Article
- Esophageal dysmotility in patients who have eosinophilic esophagitis.Gastrointestinal endoscopy clinics of North America · 2008Review
- Role of mast cells and myofibroblasts in human peritoneal adhesion formation.Annals of surgery · 2002Article
- Progression of renal disease in interleukin-4 transgenic mice: involvement of transforming growth factor-beta.International journal of experimental pathology · 1999Article
- Type VIII collagen is a product of vascular smooth-muscle cells in development and disease.The Biochemical journal · 1996Article
- Mast cells and type VIII collagen in human diabetic nephropathy.Diabetologia · 1996Article
- Mast cells in tissue response to dentistry materials: an adhesive resin, a calcium hydroxide and a glass ionomer cement.Journal of cellular and molecular medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mast cells are assuming importance not only in their familiar role in acute allergic and parasitic diseases but also in chronic inflammatory, immunologic and fibrotic states. The processes by which human extracellular matrices are influenced by mast cells have remained obscure. We report here the production of type VIII collagen by human mast cells. Mast cells representing each of the known phenotypes were identified in a variety of tissues using histochemical techniques, and monoclonal antibodies specific for tryptase, chymase, and c-kit. Mast cells in normal and pathologic tissues expressed type VIII collagen alpha-1 chain protein and mRNA, detected by immunohistochemistry using monoclonal and polyclonal antibodies, and non-isotopic oligonucleotide in situ hybridization using digoxigenin-labelled oligonucleotide probes based on the published human alpha-1 collagen VIII sequence. Perivascular location of type VIII collagen positive mast cells was a striking finding. The secretion of type VIII collagen by mast cells in vivo may contribute to angiogenesis, tissue remodelling, and fibrosis.
Indexed as
Identifiers
7734329PMC2001916W149269418What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.