ArticleThe Biochemical journal1995
Activation of the herpes simplex virus immediate-early gene promoters by neuronally expressed POU family transcription factors.
Article in The Biochemical journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 18 citations in OpenAlex.
- Reactivation of herpes simplex virus-1 following epilepsy surgery.Epilepsy & behavior case reports · 2015Article
- Cloning and initial characterization of an alternatively spliced transcript encoded by the bovine herpes virus 1 latency-related gene.Journal of neurovirology · 2003Article
- Gene array analysis reveals changes in peripheral nervous system gene expression following stimuli that result in reactivation of latent herpes simplex virus type 1: induction of transcription factor Bcl-3.Journal of virology · 2001Article
- Herpes simplex virus type 1 ICP0 protein does not accumulate in the nucleus of primary neurons in culture.Journal of virology · 2000Article
- The ability of POU family transcription factors to activate or repress gene expression is dependent on the spacing and context of their specific response elements.The Biochemical journal · 1996Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Herpes simplex virus immediate-early (IE) promoters contain the TAATGARAT motif which acts as a target site for the cellular POU family transcription factors Oct-1 and Oct-2. Here we show that other members of the POU family that are expressed in sensory neurons can also affect IE promoter activity. In particular, two members of the Brn-3 family of POU proteins Brn-3a and Brn-3c can activate the IE-1 and IE-3 promoters when co-transfected into fibroblasts and neuronal cells whereas a third member Brn-3b represses IE promoter activity. In contrast, Brn-3 proteins cannot overcome the inhibitory effect of neuronal Oct-2 on IE promoter activity in co-transfections nor do they prevent transactivation of the IE promoters by the Oct-1-Vmw65 complex. The potential regulation of the IE promoters by several different neuronally expressed POU proteins during the initiation, maintenance and re-activation of latent infection in sensory neurons is discussed.
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