ArticleThe Biochemical journal1995
Mammalian antioxidant protein complements alkylhydroperoxide reductase (ahpC) mutation in Escherichia coli.
Article in The Biochemical journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 63 citations in OpenAlex.
- Peptidomic analysis of follicular fluid in patients with polycystic ovarian syndrome.Frontiers in cell and developmental biology · 2023Article
- The Intestinal Redox System and Its Significance in Chemotherapy-Induced Intestinal Mucositis.Oxidative medicine and cellular longevity · 2022Review
- Interplay Between Mitochondrial Peroxiredoxins and ROS in Cancer Development and Progression.International journal of molecular sciences · 2019Review
- The functional role of peroxiredoxin 3 in reactive oxygen species, apoptosis, and chemoresistance of cancer cells.Journal of cancer research and clinical oncology · 2015Review
- Neurons in the hippocampal CA1 region, but not the dentate gyrus, are susceptible to oxidative stress in rats with streptozotocin-induced type 1 diabetes.Neural regeneration research · 2015Article
- A novel alkyl hydroperoxidase (AhpD) of Anabaena PCC7120 confers abiotic stress tolerance in Escherichia coli.Functional & integrative genomics · 2015Article
- Mitochondrial peroxiredoxins are critical for the maintenance of redox state and the survival of adult Drosophila.Free radical biology & medicine · 2010Article
- Construction of eukaryotic expression plasmid of human PRX3 and its expression in HEK-293FT cells.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2004Article
- The c-Myc target gene PRDX3 is required for mitochondrial homeostasis and neoplastic transformation.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Evidence that cyclophilin-A protects cells against oxidative stress.The Biochemical journal · 1999Article
- Evidence that peroxiredoxins are novel members of the thioredoxin fold superfamily.Protein science : a publication of the Protein Society · 1998Article
- Primary structure and expression of plant homologues of animal and fungal thioredoxin-dependent peroxide reductases and bacterial alkyl hydroperoxide reductases.Plant molecular biology · 1996Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The MER5 [now called the Aop1 (antioxidant protein 1) gene] was cloned as a transiently expressed gene of murine erythroleukaemia (MEL) cell differentiation and its antisense expression inhibited differentiation of MEL cells. We found that the Aop1 gene shows significant nucleotide sequence similarity to the gene coding for the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, which is also found in other bacteria, suggesting it functions as an antioxidant protein. Expression of the Aop1 gene product in E. coli deficient in the C22-subunit gene rescued resistance of the bacteria to alkylhydroperoxide. The human and mouse Aop1 genes are highly conserved, and they mapped to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian Aop1 homologues suggest that these genes consist of a family that is responsible for regulation of cellular proliferation, differentiation and antioxidant functions.
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