ArticleActa neuropathologica1995
Identification of the characteristic vascular changes in a sural nerve biopsy of a case with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Article in Acta neuropathologica, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 98 citations in OpenAlex.
- Chromosome 10q26-driven age-related macular degeneration is associated with reduced levels ofProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Differences in proliferation rate between CADASIL and control vascular smooth muscle cells are related to increased TGFβ expression.Journal of cellular and molecular medicine · 2018Article
- Role of electron microscopy in the diagnosis of cadasil syndrome: a study of 32 patients.PloS one · 2013Article
- Nerve conduction studies in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.Journal of neurology · 2009Article
- Neuropsychiatric manifestations in CADASIL.Dialogues in clinical neuroscience · 2007Review
- Single gene disorders causing ischaemic stroke.Journal of neurology · 2006Review
- Neuropathology of Charcot-Marie-Tooth and related disorders.Neuromolecular medicine · 2006Review
- Peripheral neuropathy in CADASIL.Journal of neurology · 2005Article
- Transgenic mice expressing mutant Notch3 develop vascular alterations characteristic of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.The American journal of pathology · 2003Article
- CADASIL: a common form of hereditary arteriopathy causing brain infarcts and dementia.Brain pathology (Zurich, Switzerland) · 2002Review
- A patient with cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) confirmed by sural nerve biopsy.Journal of neurology, neurosurgery, and psychiatry · 1996Article
- Systemic vascular smooth muscle cell impairment in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.Acta neuropathologica · 1995Article
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3 authors at 1 institution in 1 country.
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Abstract
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy' (CADASIL) has recently been identified as a hereditary disorder with characteristic fine structural changes of small intracerebral arteries and arterioles. Electron microscopically there are characteristic perivascular deposits of granular electron-dense material resembling immunoglobulin deposits. The present case from a family with four affected members in three successive generations shows that similar vascular changes as described in the central nervous system are present in blood vessels of the sural nerve, although less pronounced and, therefore, affording electron microscopy for their unequivocal detection. Nevertheless it has been shown for the first time that the diagnosis of CADASIL can be verified by a sural nerve biopsy. Occasional focal accumulation of pinocytotic vesicles opposite the granular deposits suggests exocytosis as one of the possible pathomechanisms for their production.
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