ArticleProceedings of the National Academy of Sciences of the United States of America1995
Maintenance of protective immunity against malaria by persistent hepatic parasites derived from irradiated sporozoites.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01082341 (Phase 1 and Phase 2a Clinical Trial), which is not on this map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Phase 1 and Phase 2a Clinical Trial:Immunization of Human Volunteers With P. Vivax Irradiated Sporozoites
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Age interactions in the development of naturally acquired immunity to Plasmodium falciparum and its clinical presentation.PLoS medicine · 2007Trial
- Complete attenuation of Plasmodium falciparum sporozoites by atovaquone-proguanil.EMBO molecular medicine · 2025Article
- Androgens inhibit protective CD8Nature communications · 2025Article
- Article
- Killing the competition: a theoretical framework for liver-stage malaria.Open biology · 2022Article
- Induction of immunity following vaccination with a chemically attenuated malaria vaccine correlates with persistent antigenic stimulation.Clinical & translational immunology · 2018Article
- Protective immunity differs between routes of administration of attenuated malaria parasites independent of parasite liver load.Scientific reports · 2017Article
- Engineering of Genetically Arrested Parasites (GAPs) For a Precision Malaria Vaccine.Frontiers in cellular and infection microbiology · 2017Review
- Malaria and the liver: immunological hide-and-seek or subversion of immunity from within?Frontiers in microbiology · 2015Review
- Memory T cells maintain protracted protection against malaria.Immunology letters · 2014Review
- Vaccines against tropical parasitic diseases: a persisting answer to a persisting problem.Nature immunology · 2014Article
- The survival of memory CD8 T cells that is mediated by IL-15 correlates with sustained protection against malaria.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Diversity covering AMA1-MSP119 fusion proteins as malaria vaccines.Infection and immunity · 2013Article
- Skin-draining lymph node priming is sufficient to induce sterile immunity against pre-erythrocytic malaria.EMBO molecular medicine · 2013Article
- Memory CD8 T cells specific for plasmodia liver-stage antigens maintain protracted protection against malaria.Frontiers in immunology · 2012Article
- CSP--a model for in vivo presentation of Plasmodium berghei sporozoite antigens by hepatocytes.PloS one · 2012Article
- Immunization with genetically attenuated P52-deficient Plasmodium berghei sporozoites induces a long-lasting effector memory CD8+ T cell response in the liver.Journal of immune based therapies and vaccines · 2011Article
- Platform for Plasmodium vivax vaccine discovery and development.Memorias do Instituto Oswaldo Cruz · 2011Review
- Early transcriptional responses of HepG2-A16 liver cells to infection by Plasmodium falciparum sporozoites.The Journal of biological chemistry · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunization of rodents and humans with irradiation-attenuated malaria sporozoites confers preerythrocytic stage-specific protective immunity to challenge infection. This immunity is directed against intrahepatic parasites and involves T cells and interferon gamma, which prevent development of exoerythrocytic stages and subsequent blood infection. The present study was undertaken to determine how protective immunity is achieved after immunization of rodent hosts with irradiated Plasmodium berghei sporozoites. We present evidence that irradiated parasites persist in hepatocytes of rats and mice for up to 6 months after immunization. A relationship between the persistence of parasites and the maintenance of protective immunity was observed. Protective immunity was abrogated in irradiated-sporozoite-immunized rats following the application of chemotherapy to remove preexisting liver parasites. Additionally, protective immunity against sporozoite challenge was established in rats vaccinated with early and late hepatic stages of irradiated parasites. These results show that irradiation-attenuated sporozoites produce persistent intrahepatic stages in vivo necessary for the induction and maintenance of protective immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.