ArticleProceedings of the National Academy of Sciences of the United States of America1995
The nucleotide sequence of chromosome I from Saccharomyces cerevisiae.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Synthetic chromosome fusion: Effects on mitotic and meiotic genome structure and function.Cell genomics · 2023Article
- From Petri Plates to Petri Nets, a revolution in yeast biology.FEMS yeast research · 2022Article
- PhyloChromoMap, a Tool for Mapping Phylogenomic History along Chromosomes, Reveals the Dynamic Nature of Karyotype Evolution in Plasmodium falciparum.Genome biology and evolution · 2018Article
- Expansion of a TelomericFrontiers in genetics · 2018Article
- The reference genome sequence of Saccharomyces cerevisiae: then and now.G3 (Bethesda, Md.) · 2014Article
- Screening for glycosylphosphatidylinositol-modified cell wall proteins in Pichia pastoris and their recombinant expression on the cell surface.Applied and environmental microbiology · 2013Article
- The modest beginnings of one genome project.Genetics · 2013Article
- TRStalker: an efficient heuristic for finding fuzzy tandem repeats.Bioinformatics (Oxford, England) · 2010Article
- A novel signal processing measure to identify exact and inexact tandem repeat patterns in DNA sequences.EURASIP journal on bioinformatics & systems biology · 2007Article
- Twofold symmetries in nucleotide distribution in large domains of Saccharomyces cerevisiae Chromosome I.Molecular genetics and genomics : MGG · 2003Article
- A novel design of whole-genome microarray probes for Saccharomyces cerevisiae which minimizes cross-hybridization.BMC genomics · 2003Article
- Transcript analysis of 1003 novel yeast genes using high-throughput northern hybridizations.The EMBO journal · 2001Article
- Chloroplast protein and centrosomal genes, a tRNA intron, and odd telomeres in an unusually compact eukaryotic genome, the cryptomonad nucleomorph.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Analysis of the seven-member AAD gene set demonstrates that genetic redundancy in yeast may be more apparent than real.Genetics · 1999Article
- Universal conservation in translation initiation revealed by human and archaeal homologs of bacterial translation initiation factor IF2.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Characterization of ATDRG1, a member of a new class of GTP-binding proteins in plants.Plant molecular biology · 1999Article
- Characterization of DRGs, developmentally regulated GTP-binding proteins, from pea and Arabidopsis.Plant molecular biology · 1999Article
- Cloning, characterization and expression of the gene coding for a cytosine-5-DNA methyltransferase recognizing GpC.Nucleic acids research · 1998Article
- SGD: Saccharomyces Genome Database.Nucleic acids research · 1998Article
- GDH3 encodes a glutamate dehydrogenase isozyme, a previously unrecognized route for glutamate biosynthesis in Saccharomyces cerevisiae.Journal of bacteriology · 1997Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromosome I from the yeast Saccharomyces cerevisiae contains a DNA molecule of approximately 231 kbp and is the smallest naturally occurring functional eukaryotic nuclear chromosome so far characterized. The nucleotide sequence of this chromosome has been determined as part of an international collaboration to sequence the entire yeast genome. The chromosome contains 89 open reading frames and 4 tRNA genes. The central 165 kbp of the chromosome resembles other large sequenced regions of the yeast genome in both its high density and distribution of genes. In contrast, the remaining sequences flanking this DNA that comprise the two ends of the chromosome and make up more than 25% of the DNA molecule have a much lower gene density, are largely not transcribed, contain no genes essential for vegetative growth, and contain several apparent pseudogenes and a 15-kbp redundant sequence. These terminally repetitive regions consist of a telomeric repeat called W', flanked by DNA closely related to the yeast FLO1 gene. The low gene density, presence of pseudogenes, and lack of expression are consistent with the idea that these terminal regions represent the yeast equivalent of heterochromatin. The occurrence of such a high proportion of DNA with so little information suggests that its presence gives this chromosome the critical length required for proper function.
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