ArticleProceedings of the National Academy of Sciences of the United States of America1995
G-utrophin, the autosomal homologue of dystrophin Dp116, is expressed in sensory ganglia and brain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 66 citations in OpenAlex.
- Targeting IRES-dependent translation as a novel approach for treating Duchenne muscular dystrophy.RNA biology · 2021Review
- Dystrophin Dp116: A yet to Be Investigated Product of the Duchenne Muscular Dystrophy Gene.Genes · 2017Review
- Structural Interface Forms and Their Involvement in Stabilization of Multidomain Proteins or Protein Complexes.International journal of molecular sciences · 2016Article
- Article
- Tissue expression and actin binding of a novel N-terminal utrophin isoform.Journal of biomedicine & biotechnology · 2011Article
- Dystrophins, utrophins, and associated scaffolding complexes: role in mammalian brain and implications for therapeutic strategies.Journal of biomedicine & biotechnology · 2010Review
- Dystrophin and utrophin isoforms are expressed in glia, but not neurons, of the avian parasympathetic ciliary ganglion.Brain research · 2008Article
- Dystrobrevin and dystrophin family gene expression in zebrafish.Gene expression patterns : GEP · 2008Article
- Dp71, utrophin and beta-dystroglycan expression and distribution in PC12/L6 cell cocultures.Neuroreport · 2007Article
- UTRN on chromosome 6q24 is mutated in multiple tumors.Oncogene · 2007Article
- Viral-mediated gene therapy for the muscular dystrophies: successes, limitations and recent advances.Biochimica et biophysica acta · 2007Review
- The dystrotelin, dystrophin and dystrobrevin superfamily: new paralogues and old isoforms.BMC genomics · 2007Article
- Dystroglycan receptor is involved in integrin activation in intestinal epithelia.American journal of physiology. Gastrointestinal and liver physiology · 2006Article
- Therapeutics for Duchenne muscular dystrophy: current approaches and future directions.Journal of molecular medicine (Berlin, Germany) · 2004Review
- Comparative analysis of vertebrate dystrophin loci indicate intron gigantism as a common feature.Genome research · 2003Article
- Distinct regions in the 3' untranslated region are responsible for targeting and stabilizing utrophin transcripts in skeletal muscle cells.The Journal of cell biology · 2001Article
- Absence of utrophin in intercalated discs of human cardiac muscle.The Histochemical journal · 2001Article
- A second promoter provides an alternative target for therapeutic up-regulation of utrophin in Duchenne muscular dystrophy.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Postsynaptic abnormalities at the neuromuscular junctions of utrophin-deficient mice.The Journal of cell biology · 1997Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The utrophin gene is closely related to the dystrophin gene in both sequence and genomic structure. The Duchenne muscular dystrophy (DMD) locus encodes three 14-kb dystrophin transcripts in addition to several smaller isoforms, one of which, Dp116, is specific to peripheral nerve. We describe here the corresponding 5.5-kb mRNA from the utrophin locus. This transcript, designated G-utrophin, is of particular interest because it is specifically expressed in the adult mouse brain and appears to be the predominant utrophin transcript in this tissue. G-utrophin is expressed in brain sites generally different from the regions expressing beta-dystroglycan. During mouse embryogenesis G-utrophin is also seen in the developing sensory ganglia. Our data confirm the close evolutionary relationships between the DMD and utrophin loci; however, the functions for the corresponding proteins probably differ.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.