ArticleNucleic acids research1995
A modified single-strand annealing model best explains the joining of DNA double-strand breaks mammalian cells and cell extracts.
Article in Nucleic acids research, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Efficient CRISPR-based genome editing using tandem guide RNAs and editable surrogate reporters.FEBS open bio · 2018Article
- Targeted DNA excision in Arabidopsis by a re-engineered homing endonuclease.BMC biotechnology · 2012Article
- Anti-apoptotic protein BCL2 down-regulates DNA end joining in cancer cells.The Journal of biological chemistry · 2010Article
- Non-homologous DNA end joining in normal and cancer cells and its dependence on break structures.Genetics and molecular biology · 2010Article
- Article
- Efficient repair of genomic double-strand breaks by homologous recombination between directly repeated sequences in the plant genome.The Plant cell · 2002Article
- The role of DNA polymerase activity in human non-homologous end joining.Nucleic acids research · 2001Article
- Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals.The Journal of experimental medicine · 2000Article
- Species-specific double-strand break repair and genome evolution in plants.The EMBO journal · 2000Article
- DNA double-strand break repair in cell-free extracts from Ku80-deficient cells: implications for Ku serving as an alignment factor in non-homologous DNA end joining.Nucleic acids research · 2000Article
- Multiple pathways for repair of DNA double-strand breaks in mammalian chromosomes.Molecular and cellular biology · 1999Article
- Capture of genomic and T-DNA sequences during double-strand break repair in somatic plant cells.The EMBO journal · 1998Article
- Radiation-induced chromosome aberrations in Saccharomyces cerevisiae: influence of DNA repair pathways.Genetics · 1998Article
- Chromosomal double-strand breaks induce gene conversion at high frequency in mammalian cells.Molecular and cellular biology · 1997Article
- Drosophila P-element transposase is a novel site-specific endonuclease.Genes & development · 1997Article
- Processing of DNA prior to illegitimate recombination in mouse cells.Molecular and cellular biology · 1997Article
- The RAD5 gene product is involved in the avoidance of non-homologous end-joining of DNA double strand breaks in the yeast Saccharomyces cerevisiae.Nucleic acids research · 1997Article
- The joining of non-complementary DNA double-strand breaks by mammalian extracts.Nucleic acids research · 1996Article
- Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae.Molecular and cellular biology · 1996Article
- The Saccharomyces cerevisiae Ku autoantigen homologue affects radiosensitivity only in the absence of homologous recombination.Genetics · 1996Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The joining of DNA double-strand breaks in vivo is frequently accompanied by the loss of a few nucleotides at the junction between the interacting partners. In vitro systems mimic this loss and, on detailed analysis, have suggested two models for the mechanism of end-joining. One invokes the use of extensive homologous side-by-side alignment of the partners prior to joining, while the other proposes the use of small regions of homology located at or near the terminus of the interacting molecules. to discriminate between these two models, assays were conducted both in vitro and in vivo with specially designed substrates. In vitro, molecules with limited terminal homology were capable of joining, but analysis of the junctions suggested that the mechanism employed the limited homology available. In vivo, the substrates with no extensive homology end-joined with equal efficiency to those with extensive homology in two different topological arrangements. Taken together, these results suggest that extensive homology is not a prerequisite for efficient end-joining, but that small homologies close to the terminus are used preferentially, as predicted by the modified single-strand annealing model.
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