ArticleThe Journal of general physiology1995
Plasticity in canine airway smooth muscle.
Article in The Journal of general physiology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed.
- Reproducibility of smooth muscle mechanical properties in consecutive stretch and activation protocols.Pflugers Archiv : European journal of physiology · 2025Article
- Effects of increasing tidal volume and end-expiratory lung volume on induced bronchoconstriction in healthy humans.Respiratory research · 2024Article
- A life off the beaten track in biomechanics: Imperfect elasticity, cytoskeletal glassiness, and epithelial unjamming.Biophysics reviews · 2023Review
- Membrane adhesion junctions regulate airway smooth muscle phenotype and function.Physiological reviews · 2023Review
- Vascular mechanotransduction.Physiological reviews · 2023Review
- Review
- Filament evanescence of myosin II and smooth muscle function.The Journal of general physiology · 2021Review
- The Force Awakens in the Cytoskeleton: The Saga of a Shape-Shifter.American journal of respiratory cell and molecular biology · 2020Article
- Airway smooth muscle adapting in dynamic conditions is refractory to the bronchodilator effect of a deep inspiration.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Quantitative in situ proximity ligation assays examining protein interactions and phosphorylation during smooth muscle contractions.Analytical biochemistry · 2019Article
- Molecular Mechanisms for the Mechanical Modulation of Airway Responsiveness.Journal of engineering and science in medical diagnostics and therapy · 2019Article
- Article
- The actin regulator zyxin reinforces airway smooth muscle and accumulates in airways of fatal asthmatics.PloS one · 2017Article
- Peripheral Airway Smooth Muscle, but Not the Trachealis, Is Hypercontractile in an Equine Model of Asthma.American journal of respiratory cell and molecular biology · 2016Article
- Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle Disorders.Pharmacological reviews · 2016Review
- Airway hyperresponsiveness; smooth muscle as the principal actor.F1000Research · 2016Review
- Myosin filaments in smooth muscle cells do not have a constant length.The Journal of physiology · 2013Article
- Can tidal breathing with deep inspirations of intact airways create sustained bronchoprotection or bronchodilation?Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Increased mechanical strain imposed on murine lungs during ventilation in vivo depresses airway responsiveness and activation of protein kinase Akt.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Airway Smooth Muscle Dynamics and Hyperresponsiveness: In and outside the Clinic.Journal of allergy · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The large volume changes of some hollow viscera require a greater length range for the smooth muscle of their walls than can be accommodated by a fixed array of sliding filaments. A possible explanation is that smooth muscles adapt to length changes by forming variable numbers of contractile units in series. To test for such plasticity we examined the muscle length dependence of shortening velocity and compliance, both of which will vary directly with the number of thick filaments in series. Dog tracheal smooth muscle was studied because its cells are arrayed in long, straight, parallel bundles that span the length of the preparation. In experiments where muscle length was changed, both compliance and velocity showed a strong dependence on muscle length, varying by 1.7-fold and 2.2-fold, respectively, over a threefold range of length. The variation in isometric force was substantially less, ranging from a 1.2- to 1.3-fold in two series of experiments where length was varied by twofold to an insignificant 4% variation in a third series where a threefold length range was studied. Tetanic force was below its steady level after both stretches and releases, and increased to a steady level with 5-6 tetani at 5 min intervals. These results suggest strongly that the number of contractile units in series varies directly with the adapted muscle length. Temporary force depression after a length change would occur if the change transiently moved the filaments from their optimum overlap. The relative length independence of the adapted force is explained by the reforming of the filament lattice to produce optimum force development, with commensurate changes of velocity and compliance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.